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Table 6 Association between pain intensity and COMT rs4680 polymorphism in the studies included in the systematic review

From: Opioid response in paediatric cancer patients and the Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene: an Italian study on 87 cancer children and a systematic review

Study name [ref]

Variable

Genotype frequency (N, %)

Results (type of measure)

p-value

EPOS study [20] (Barratt, 2015)

Brief Pain Inventory

G/G (109, 23.59)

A/G (243, 52.60)

A/A (110, 23.80)

Not reported

 

[23] RakvĂĄg, 2005

Brief Pain Inventory after 24 h

G/G (44, 21.25)

A/G (96, 46.38)

A/A (67, 32.37)

3.9 ± 2.2

3.7 ± 2.6

3.5 ± 2.3

(mean ± SD)

> 0.05

[28] Ross, 2008

Brief Pain Inventory after 24 h

G/G (46, 20.81)

A/G (119, 53.85)

A/A (56, 25.34)

Not reported

0.897