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Table 6 Association between pain intensity and COMT rs4680 polymorphism in the studies included in the systematic review

From: Opioid response in paediatric cancer patients and the Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene: an Italian study on 87 cancer children and a systematic review

Study name [ref] Variable Genotype frequency (N, %) Results (type of measure) p-value
EPOS study [20] (Barratt, 2015) Brief Pain Inventory G/G (109, 23.59)
A/G (243, 52.60)
A/A (110, 23.80)
Not reported  
[23] Rakvåg, 2005 Brief Pain Inventory after 24 h G/G (44, 21.25)
A/G (96, 46.38)
A/A (67, 32.37)
3.9 ± 2.2
3.7 ± 2.6
3.5 ± 2.3
(mean ± SD)
> 0.05
[28] Ross, 2008 Brief Pain Inventory after 24 h G/G (46, 20.81)
A/G (119, 53.85)
A/A (56, 25.34)
Not reported 0.897