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Table 5 Association between opioid dose and COMT rs4680 polymorphism in the studies included in the systematic review

From: Opioid response in paediatric cancer patients and the Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene: an Italian study on 87 cancer children and a systematic review

Study name [ref] Variable Genotype frequency
(N, %)
Results (type of measure) p-value
EPOS study [18] (Klepstad, 2011) Dose in mg after 24 h G/G (324, 22.18)
A/G (726, 49.69)
A/A (411, 28.13)
180 mg
180 mg
160 mg (median)
0.545
[22] Matsuoka, 2012 Dose in mg after 24 h G/G (19, 46.34)
A/G (18, 43.90)
A/A (4, 9.76)
43.7 ± 21.4
28.9 ± 3.2
30.0 ± 0.0 (mean ± SD)
0.03
[23] Rakvåg, 2005 Dose in mg after 24 h G/G (44, 21.25)
A/G (96, 46.38)
A/A (67, 32.37)
155 ± 160
117 ± 100
95 ± 99 (mean ± SD)
0.025
[26] Chatti, 2016 Total dose requirement
(continuous) AvsG
G/G (30, 23.3)
A/G (57, 44.2)
A/A (42, 32.6)
−2.10 (difference) 0.334
  Need of escalation
(yes/no) AvsG
  OR 0.76 (0.45; 1.27) 0.293