N (%) ORa (95% CI) | |||
---|---|---|---|
G/G | A/G | A/A | |
Dose (mg/kg) | |||
High Dose24h (≥0.41 vs < 0.41) | 12 (50.00) vs 12 (50.00) | 21 (52.50) vs 19 (47.50) | 7 (53.85) vs 6 (46.15) |
1 (reference) | 0.66 (0.19–2.25) | 0.80 (0.16–4.01) | |
High Dosetot (≥2.18 vs < 2.18) | 16 (66.67) vs 8 (33.33) | 18 (42.86) vs 24 (57.14) | 7 (53.85) vs 6 (46.15) |
1 (reference) | 0.27 (0.08–0.87) | 0.42 (0.09–1.98) | |
High DoseVAS = 0 (≥0.26 vs < 0.26) | 14 (58.33) vs 10 (41.67) | 26 (65.00) vs 14 (35.00) | 9 (69.23) vs 4 (30.77) |
1 (reference) | 0.98 (0.30–3.24) | 1.47 (0.29–7.40) | |
Pain Intensity | |||
High ∆VAS (≥2 vs < 2) | 14 (58.33) vs 10 (41.67) | 20 (47.62) vs 22 (52.38) | 6 (46.15) vs 7 (53.85) |
1 (reference) | 0.51 (0.15–1.65) | 0.57 (0.12–2.82) | |
High Timetot (≥133 vs < 133) | 19 (79.17) vs 5 (20.83) | 19 (45.24) vs 23 (54.76) | 4 (30.77) vs 9 (69.23) |
1 (reference) | 0.18 (0.05–0.63) | 0.11 (0.02–0.56) | |
Side effects, N (%) | |||
Gastrointestinalb | 8 (33.33) vs 16 (66.67) | 9 (21.43) vs 33 (78.57) | 3 (23.08) vs 10 (76.92) |
1 (reference) | 0.56 (0.16–1.91) | 0.46 (0.09–2.44) | |
CNSc | 2 (8.33) vs 22 (91.67) | 4 (9.52) vs 38 (90.48) | 2 (15.38) vs 11 (84.62) |
1 (reference) | 1.39 (0.21–9.44) | 1.62 (0.17–15.78) | |
Totald | 10 (58.33) vs 10 (41.67) | 14 (33.33) vs 28 (66.67) | 4 (30.77) vs 9 (69.23) |
1 (reference) | 0.86 (0.29–2.56) | 0.58 (0.13–2.54) |