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Table 1 Characteristics of the 87 Italian subjects included in the STOP Pain Project: overall and stratified for COMT rs4680 polymorphism

From: Opioid response in paediatric cancer patients and the Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene: an Italian study on 87 cancer children and a systematic review

  Overall G/Ga A/Ga A/Aa p-value b
N (%) N (%) N (%) N (%)
  87 24 (30.38) 42 (53.16) 13 (16.46)  
Gender
 Male 49 (56.32) 15 (62.50) 22 (52.38) 7 (53.85) 0.721
 Female 38 (43.68) 9 (37.50) 20 (47.62) 6 (46.15)
Age (months)
 0–36 18 (20.69) 4 (16.67) 8 (19.05) 4 (30.77) 0.466
  > 36–144 32 (36.78) 10 (41.67) 18 (42.86) 2 (15.38)
  > 144 37 (42.53) 10 (41.67) 16 (38.10) 7 (53.85)
BMI (percentile)
  < 25th 33 (42.31) 5 (25.00) 18 (46.15) 5 (38.46) 0.490
 25th- < 75th 20 (25.64) 8 (40.00) 8 (20.51) 4 (30.77)
  ≥ 75th 25 (32.05) 7 (35.00) 13 (33.33) 4 (30.77)
missing 9     
Diagnosis
 Brain Tumour 6 (6.90) 2 (8.33) 2 (4.76) 0.728
 Leukaemia and Lymphoma 34 (39.08) 11 (45.83) 18 (42.86) 4 (30.77)
 Neuroblastoma 6 (6.90) 1 (4.17) 3 (7.14) 2 (15.38)
 Osteosarcoma 17 (19.54) 2 (8.33) 8 (19.05) 3 (23.08)
 Sarcoma 18 (20.69) 7 (29.17) 8 (19.05) 2 (15.38)
 Others 6 (6.90) 1 (4.17) 3 (7.14) 2 (15.38)
Metastasis
 No 64 (73.56) 19 (79.17) 26 (61.90) 12 (92.31) 0.067
 Yes 23 (26.44) 5 (20.83) 16 (38.10) 1 (7.69)
Pain location
 Abdominal 12 (13.79) 5 (20.83) 4 (9.52) 2 (15.38) 0.808
 Oral cavity 43 (49.43) 11 (45.83) 23 (54.76) 6 (46.15)
 Skeletal – Muscle 14 (16.09) 3 (12.50) 5 (11.90) 3 (23.08)
 Other 18 (20.69) 5 (20.83) 10 (23.81) 2 (15.38)
Pain Intensity (PIto), mean (95% CI) 4.34 (3.88–4.81) 4.08 (3.33–4.84) 4.57 (3.89–5.25) 4.38 (2.81–5.96) 0.674a
Drug
 morphine 60 (68.97) 16 (66.67) 32 (76.19) 8 (61.54)  
 tramadol 19 (21.84) 5 (20.83) 9 (21.43) 3 (23.08) 0.632
 oxycodone 2 (2.30) 1 (4.17)
 codeine 2 (2.30) 1 (4.17) 1 (7.69)
 more than one 4 (4.60) 1 (4.17) 1 (2.38) 1 (7.69)
  1. a Biological samples of 8 patients were not available for medical reasons. Genetic data were not available for technical reasons (failure of the genetic test)
  2. b p-value from ANOVA