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Fig. 4 | BMC Cancer

Fig. 4

From: Fascin-1 enhances experimental osteosarcoma tumor formation and metastasis and is related to poor patient outcome

Fig. 4

Fascin-1 overexpression in SaOS-2 cells promotes intratibial primary tumor growth and lung metastasis in SCID mice. (a) Representative X-ray images of tumor-bearing hind limbs of mice injected with SaOS-2/EV cells (upper panel) or with SaOS-2/Fascin-1 (lower panel). The images show primary tumor appearance on indicated days after tumor cell injection. (b) Representative X-ray images of tumor-bearing hind limbs of mice injected with SaOS-2/Ctrl ShRNA cells (upper panel) or with SaOS-2/ShFascin-1 cells (lower panel). (c) Mean primary tumor growth over time in mice intratibially injected with SaOS-2/EV cells (black), with SaOS-2/Fascin-1 cells (red), with SaOS-2/Ctrl ShRNA (grey) or with SaOS-2/ShFascin-1 blue). (d) Mean number ± SEM of metastatic lesions in the lungs

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