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Table 3 Chemotherapy-induced peripheral neuropathy prevalence by 6 different chemotherapy drugs

From: Are we mis-estimating chemotherapy-induced peripheral neuropathy? Analysis of assessment methodologies from a prospective, multinational, longitudinal cohort study of patients receiving neurotoxic chemotherapy

CIPN measures Samples Baseline Cycle1 Cycle2 Cycle3 Cycle4 Cycle5 Cycle6 6mFU 9mFU 12mFU
n/N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%)
NCI motor 1
(> = grade2)
Docetaxel 2/122 (1.6) 3/122 (2.7) 4/109 (3.7) 13/105 (12.4) 21/95 (22.1) 9/41 (22) 8/38 (21.1) 20/96 (20.8) 19/89 (21.3) 12/84 (14.3)
Paclitaxel 0/33 (0) 3/33 (9.1) 2/31 (6.6) 2/31 (6.4) 0/28 (0) 0/13 (0) 1/13 (7.7) 5/27 (18.5) 3/21 (14.3) 1/15 (6.7)
Cisplatin/Carboplatin 1/80 (1.2) 2/65 (3.1) 5/57 (8.8) 6/46 (13) 4/32 (12.5) 1/9 (11.1) 0/6 (0) 3/43 (7) 3/39 (7.7) 2/32 (6.2)
Oxaliplatin 0/28 (0) 2/26 (7.7) 2/25 (8) 0/22 (0) 0/22 (0) 0/16 (0) 1/11 (9.1) 1/21 (4.8) 0/17 (0) 0/12 (0)
Carboplatin+paclitaxel 0/49 (0) 3/44 (6.8) 2/42 (4.8) 6/42 (14.3) 6/38 (15.8) 6/30 (20) 5/24 (20.8) 14/24 (58.3) 5/40 (12.5) 2/24 (8.3)
Carboplatin+docetaxel 0/29 (0) 1/28 (3.6) 2/26 (7.7) 2/27 (7.4) 2/27 (7.4) 5/26 (17.9) 6/28 (21.4) 1/28 (3.6) 0/28 (0) 0/27 (0)
NCI sensory1
(> = grade2)
Docetaxel 0/122 (0) 1/122 (0.9) 4/109 (3.7) 7/105 (6.7) 10/95 (10.5) 5/41 (12.2) 4/38 (10.5) 17/96 (17.7) 17/89 (19.1) 9/84 (10.7)
Paclitaxel 0/33 (0) 3/33 (9.1) 3/31 (9.7) 2/31 (6.14) 0/28 (0) 0/18 (0) 3/13 (23.1) 7/27 (25.9) 4/21 (19) 2/15 (13.4)
Cisplatin/Carboplatin 1/80 (1.2) 0/65 (0) 4/57 (7.0) 4/46 (8.7) 2/32 (6.3) 1/9 (11.1) 0/6 (0) 2/43 (4.7) 3/39 (7.7) 2/32 (6.2)
Oxaliplatin 0/28 (0) 2/26 (7.7) 2/25 (8) 0/22 (0) 0/22 (0) 0/16 (0) 1/11 (9.1) 1/21 (4.8) 1/17 (5.9) 0/12 (0)
Carboplatin+paclitaxel 0/49 (0) 5/44 (11.4) 3/42 (7.1) 5/42 (11.9) 7/38 (18.4) 7/30 (23.3) 7/27 (29.2) 6/40 (15) 4/40 (10) 3/24 (12.5)
Carboplatin+docetaxel 0/29 (0) 0/28 (0) 1/26 (3.8) 1/27 (3.7) 1/27 (3.7) 3/28 (10.7) 2/28 (7.1) 0/28 (0) 0/28 (0) 0/27 (0)
WHO-CIPN 2
(> = grade 1)
Docetaxel 1/122 (0.8) 3/122 (2.7) 5/109 (4.6) 8/105 (7.6) 11/95 (11.6) 7/41 (17.1) 5/38 (13.2) 16/96 (16.7) 15/89 (16.9) 9/84 (10.7)
Paclitaxel 2/33 (6.1) 9/33 (27.3) 10/31 (32.3) 16/31 (51.6) 16/28 (57.1) 0/18 (0) 7/13 (53.8) 14/27 (51.9) 8/21 (38.1) 2/15 (13.3)
Cisplatin/Carboplatin 1/80 (1.2) 2/65 (3) 6/57 (10.5) 3/46 (6.5) 1/32 (3.1) 0/9 (0) 0/6 (0) 2/43 (4.7) 1/39 (2.6) 1/32 (3.1)
Oxaliplatin 2/28 (7.1) 6/26 (23.1) 9/25 (36) 14/22 (63.6) 12/22 (54.5) 9/16 (56.3) 3/11 (27.3) 4/21 (19) 6/17 (35.3) 1/12 (8.3)
Carboplatin+paclitaxel 2/49 (4) 11/44 (25) 12/42 (28.6) 15/42 (35.7) 19/38 (50) 13/30 (43.3) 5/19 (20.8) 7/40 (17.5) 7/40 (17.5) 1/24 (4.2)
Carboplatin+docetaxel 0/29 (0) 0/28 (0) 0/26 (0) 0/27 (0) 1/27 (3.7) 2/28 (7.1) 3/28 (10.7) 2/28 (7.1) 0/28 (0) 0/27 (0)
Cotton wool(+)3 Docetaxel 1/113 (0.9) 2/104 (1.9) 2/104 (1.9) 2/100 (1.2) 1/84 (1.2) 1/38 (2.6) 2/31 (6.5) 6/82 (7.3) 4/64 (6.3) 2/57 (3.5)
Paclitaxel 0/31 (0) 3/33 (9.1) 1/29 (3.4) 5/29 (17.2) 0/28 (0) 2/18 (11.1) 1/13 (7.7) 7/25 (28) 7/20 (35) 2/14 (14.3)
Cisplatin/Carboplatin 0/65 (0) 1/55 (1.8) 0/48 (0.0) 0/43 (0) 0/16 (0) 0/8 (0) 0/3 (0) 1/29 (3.4) 2/26 (7.7) 0/19 0)
Oxaliplatin 0/27 (0) 3/25 (12.0) 3/25 (12) 5/22 (22.7) 3/16 (18.8) 2/12 (16.7) 8/20 (40) 3/16 (18.8) 1/12 (8.3) 1/12 (8.3)
Carboplatin+paclitaxel 0/49 (0) 6/36 (8.3) 4/35 (11.4) 8/36 (22.2) 6/29 (17.1) 4/27 (14.8) 1/20 (5) 6/33 (18.2) 4/31 (12.9) 0/16 (0)
Carboplatin+docetaxel 0/29 (0) 0/28 (0) 0/26 (0) 0/27 (0) 0/27 (0) 1/28 (3.6) 1/28 (3.6) 1/28 (3.6) 0/26 (0) 0/25 (0)
Monofilame-nt(+)3 Docetaxel 1/116 (0.9) 2/109 (1.8) 4/109 (3.7) 5/105 (4.8) 7/88 (8) 5/41 (12.2) 5/31 (16.1) 16/85 (18.8) 12/68 (17.6) 4/57 (7.0)
Paclitaxel 1/33 (3.0) 9/33 (27.3) 3/31 (9.7) 5/31 (16.1) 0/31 (0) 1/18 (5.6) 1/13 (7.7) 7/27 (25.9) 8/21 (38.1) 3/15 (20.0)
Cisplatin/Carboplatin 0/77 (0) 1/63 (1.6) 2/57 (3.5) 2/46 (4.3) 1/17 (5.9) 1/9 (0) 0/3 (0) 3/33 (9.1) 3/29 (10.3) 0/21 (0)
Oxaliplatin 0/28 (0) 2/26 (7.7) 3/25 (12) 4/22 (18.2) 2/22 (9.1) 3/16 (18.8) 1/11 (9.1) 7/21 (33.3) 4/17 (23.5) 1/12 (8.3)
Carboplatin+paclitaxel 0/49 (0) 4/43 (9.3) 6/42 (14.3) 11/42 (26.2) 11/38 (28.9) 9/30 (30) 4/20 (20) 10/38 (26.3) 7/35 (20) 2/17 (11.8)
Carboplatin+docetaxel 0/29 (0) 0/28 (0) 0/26 (0) 0/27 (0) 1/27 (3.7) 2/28 (7.1) 3/28 (10.7) 2/28 (7.1) 0/26 (0) 0/25 (0)
FACTGOG-Ntx
Numbness/tingling in hands 5
(>grade = 1)
Docetaxel 21/122 (17.2) 20/113 (17.7) 26/109 (23.9) 29/105 (27.6) 36/96 (37.5) 19/41 (46.3) 17/38 (44.7) 41/96 (42.7) 36/90 (40) 22/84 (26.2)
Paclitaxel 7/33 (21.2) 11/32 (34.4) 13/31 (41.9) 15/31 (41.9) 13/28 (48.4) 8/18 (44.4) 9/13 (69.2) 17/27 (63) 11/21 (52.4) 10/15 (66.7)
Cisplatin/Carboplatin 11/81 (13.6) 7/66 (10.6) 9/57 (15.8) 9/47 (19.1) 6/32 (18.7) 2/9 (22.2) 3/6 (50) 11/43 (25.6) 7/39 (17.9) 3/32 (9.4)
Oxaliplatin 2/28 (7.1) 10/24 (41.7) 15/26 (65.2) 15/20 (75) 15/20 (75) 8/14 (57.1) 5/9 (55.6) 15/21 (71.4) 11/17 (64.7) 10/12 (83.3)
Carboplatin+paclitaxel 5/50 (10) 23/44 (52.4) 25/41 (61.0) 22/41 (53.7) 22/37 (59.5) 18/28 (64.3) 13/25 (52) 22/40 (55) 16/40 (40) 8/25 (32)
Carboplatin+docetaxel 1/29 (3.4) 1/28 (3.6) 5/26 (19.2) 3/27 (11.1) 4/27 (14.8) 8/28 (28.6) 12/28 (42.9) 10/28 (35.7) 6/28 (21.4) 5/27 (18.5)
FACTGOG-Ntx Numbness/tingling in feet 5
(>grade = 1)
Docetaxel 6/122 (4.9) 10/113 (8.8) 12/109 (11) 22/105 (21) 29/96 (30.2) 12/41 (29.3) 9/38 (23.7) 37/96 (38.5) 31/90 (34.4) 21/84 (25.0)
Paclitaxel 5/32 (15.6) 11/31 (35.5) 13/31 (41.9) 15/31 (8.4) 14/28 (50) 8/18 (44.4) 7/13 (53.8) 16/27 (59.3) 10/21 (47.6) 7/15 (46.7)
Cisplatin/Carboplatin 5/81 (6.2) 7/66 (10.6) 5/57 (8.8) 7/47 (14.9) 7/32 (21.9) 3/9 (33.3) 3/6 (50) 14/43 (32.6) 8/39 (20.5) 2/32 (6.2)
Oxaliplatin 2/28 (7.2) 9/27 (37.5) 16/23 (69.6) 13/20 (65) 15/20 (75) 8/14 (57.1) 3/9 (33.3) 15/21 (71.4) 5/21 (23.8) 9/12 (75.0)
Carboplatin+paclitaxel 5/50 (10) 20/44 (45.5) 22/41 (53.7) 26/41 (63.4) 23/37 (62.2) 20/28 (71.4) 13/25 (52) 26/40 (75) 19/40 (47.5) 8/25 (32)
Carboplatin+docetaxel 1/29 (3.4) 2/28 (7.1) 4/26 (15.4) 5/27 (18.5) 6/27 (22.2) 8/28 (28.6) 13/28 (46.4) 10/28 (35.7) 6/28 (21.4) 5/27 (18.5)
ECIPN-20 (item 3) Numbness inhands/fingers 4
(> = grade 2)
Docetaxel 26/122 (21.3) 22/113 (19.5) 24/109 (22) 31/105 (29.5) 36/96 (37.5) 17/41 (41.5) 18/38 (47.4) 41/96 (42.7) 36/89 (40.4) 25/84 (29.8)
Paclitaxel 6/33 (18.2) 11/31 (35.5) 13/31 (41.9) 14/31 (45.2) 13/28 (46.4) 6/18 (33.3) 10/13 (76.9) 10/27 (59.3) 10/21 (47.6) 8/15 (53.3)
Cisplatin/Carboplatin 12/81 (14.8) 5/66 (7.6) 9/57 (15.8) 9/47 (19.1) 6/32 (18.7) 3/9 (33.3) 3/6 (50) 11/43 25.6) 8/39 (20.5) 4/32 (22.5)
Oxaliplatin 6/28 (21.4) 14/24 (58.8) 17/23 (73.9) 14/20 (70.0) 14/20 (70.0) 8/14 (57.1) 6/9 (66.6) 14/21 (66.7) 10/17 (38.1) 8/12 (66.7)
Carboplatin+paclitaxel 5/50 (10) 20/44 (45.5) 22/41 (53.7) 23/41 (56.1) 23/37 (62.2) 15/28 (53.6) 13/24 (54.2) 22/40 (55) 16/40 (40) 10/25 (40)
Carboplatin+docetaxel 2/29 (6.9) 2/28 (7.1) 4/26 (15.4) 4/27 (14.8) 4/27 (14.8) 7/28 (25) 11/28 (39.3) 9/28 (32.1) 7/28 (25) 6/27 (22.2)
ECIPN-20 (item 4) Numbness in feet/toes 4
(> = grade 2)
Docetaxel 8/122 (6.6) 12/113 (10.6) 15/109 (13.8) 23/105 (21.9) 30/96 (31.2) 10/41 (24.4) 11/38 (29.0) 37/96 (38.5) 31/90 (34.4) 24/84 (28.6)
Paclitaxel 7/33 (21.2) 12/32 (37.5) 11/31 (35.5) 11/31 (35.5) 14/28 (50.0) 9/18 (50.0) 8/13 (61.5) 15/27 (55.6)   6/15 (40)
Cisplatin/Carboplatin 8/81 (9.9) 4/66 (6.1) 6/57 (10.5) 7/47 (14.9) 5/32 (15.6) 3/9 (33.3) 3/6 (50) 11/43 (25.6) 9/39 (23.1) 3/32 (9.4)
Oxaliplatin 3/28 (10.7) 10/24 (41.7) 14/9 (60.1) 14/20 (70.0) 14/20 (70) 7/14 (50.0) 4/9 (44.4) 13/21 (61.9) 10/17 (58.8) 8/12 (66.7)
Carboplatin+paclitaxel 7/50 (14) 23/44 (52.3) 21/41951.2) 24/41 (58.5) 25/37 (67.6) 20/28 (71.4) 15/24 (62.5) 27/40 (67.5) 21/40 (52.5) 11/25 (440
Carboplatin+docetaxel 2/29 (6.9) 2/28 (7.1) 3/26 (11.5) 4/27 (14.8) 6/27 (22.2) 8/28 (28.6) 13/28 (46.4) 10/28 (35.7) 6/28 (21.4) 5/27 (18.5)
  1. 1NCI motor/sensory (>grade 2 = Moderate symptoms limiting instrumental ADL); 2 WHO CIPN (> = Grade 1 = Paresthesias and/or decreased tendon reflexes); 3 cotton wool/monofilament (+) = (abnormal sensation, a lot/a little/no sensation); 4 ECIPN-20 (> = grade 2 = A little); 5 FACTGOG-Ntx (> = 1 = a little bit)