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Table 3 Chemotherapy-induced peripheral neuropathy prevalence by 6 different chemotherapy drugs

From: Are we mis-estimating chemotherapy-induced peripheral neuropathy? Analysis of assessment methodologies from a prospective, multinational, longitudinal cohort study of patients receiving neurotoxic chemotherapy

CIPN measures

Samples

Baseline

Cycle1

Cycle2

Cycle3

Cycle4

Cycle5

Cycle6

6mFU

9mFU

12mFU

n/N (%)

N (%)

N (%)

N (%)

N (%)

N (%)

N (%)

N (%)

N (%)

N (%)

NCI motor 1

(> = grade2)

Docetaxel

2/122 (1.6)

3/122 (2.7)

4/109 (3.7)

13/105 (12.4)

21/95 (22.1)

9/41 (22)

8/38 (21.1)

20/96 (20.8)

19/89 (21.3)

12/84 (14.3)

Paclitaxel

0/33 (0)

3/33 (9.1)

2/31 (6.6)

2/31 (6.4)

0/28 (0)

0/13 (0)

1/13 (7.7)

5/27 (18.5)

3/21 (14.3)

1/15 (6.7)

Cisplatin/Carboplatin

1/80 (1.2)

2/65 (3.1)

5/57 (8.8)

6/46 (13)

4/32 (12.5)

1/9 (11.1)

0/6 (0)

3/43 (7)

3/39 (7.7)

2/32 (6.2)

Oxaliplatin

0/28 (0)

2/26 (7.7)

2/25 (8)

0/22 (0)

0/22 (0)

0/16 (0)

1/11 (9.1)

1/21 (4.8)

0/17 (0)

0/12 (0)

Carboplatin+paclitaxel

0/49 (0)

3/44 (6.8)

2/42 (4.8)

6/42 (14.3)

6/38 (15.8)

6/30 (20)

5/24 (20.8)

14/24 (58.3)

5/40 (12.5)

2/24 (8.3)

Carboplatin+docetaxel

0/29 (0)

1/28 (3.6)

2/26 (7.7)

2/27 (7.4)

2/27 (7.4)

5/26 (17.9)

6/28 (21.4)

1/28 (3.6)

0/28 (0)

0/27 (0)

NCI sensory1

(> = grade2)

Docetaxel

0/122 (0)

1/122 (0.9)

4/109 (3.7)

7/105 (6.7)

10/95 (10.5)

5/41 (12.2)

4/38 (10.5)

17/96 (17.7)

17/89 (19.1)

9/84 (10.7)

Paclitaxel

0/33 (0)

3/33 (9.1)

3/31 (9.7)

2/31 (6.14)

0/28 (0)

0/18 (0)

3/13 (23.1)

7/27 (25.9)

4/21 (19)

2/15 (13.4)

Cisplatin/Carboplatin

1/80 (1.2)

0/65 (0)

4/57 (7.0)

4/46 (8.7)

2/32 (6.3)

1/9 (11.1)

0/6 (0)

2/43 (4.7)

3/39 (7.7)

2/32 (6.2)

Oxaliplatin

0/28 (0)

2/26 (7.7)

2/25 (8)

0/22 (0)

0/22 (0)

0/16 (0)

1/11 (9.1)

1/21 (4.8)

1/17 (5.9)

0/12 (0)

Carboplatin+paclitaxel

0/49 (0)

5/44 (11.4)

3/42 (7.1)

5/42 (11.9)

7/38 (18.4)

7/30 (23.3)

7/27 (29.2)

6/40 (15)

4/40 (10)

3/24 (12.5)

Carboplatin+docetaxel

0/29 (0)

0/28 (0)

1/26 (3.8)

1/27 (3.7)

1/27 (3.7)

3/28 (10.7)

2/28 (7.1)

0/28 (0)

0/28 (0)

0/27 (0)

WHO-CIPN 2

(> = grade 1)

Docetaxel

1/122 (0.8)

3/122 (2.7)

5/109 (4.6)

8/105 (7.6)

11/95 (11.6)

7/41 (17.1)

5/38 (13.2)

16/96 (16.7)

15/89 (16.9)

9/84 (10.7)

Paclitaxel

2/33 (6.1)

9/33 (27.3)

10/31 (32.3)

16/31 (51.6)

16/28 (57.1)

0/18 (0)

7/13 (53.8)

14/27 (51.9)

8/21 (38.1)

2/15 (13.3)

Cisplatin/Carboplatin

1/80 (1.2)

2/65 (3)

6/57 (10.5)

3/46 (6.5)

1/32 (3.1)

0/9 (0)

0/6 (0)

2/43 (4.7)

1/39 (2.6)

1/32 (3.1)

Oxaliplatin

2/28 (7.1)

6/26 (23.1)

9/25 (36)

14/22 (63.6)

12/22 (54.5)

9/16 (56.3)

3/11 (27.3)

4/21 (19)

6/17 (35.3)

1/12 (8.3)

Carboplatin+paclitaxel

2/49 (4)

11/44 (25)

12/42 (28.6)

15/42 (35.7)

19/38 (50)

13/30 (43.3)

5/19 (20.8)

7/40 (17.5)

7/40 (17.5)

1/24 (4.2)

Carboplatin+docetaxel

0/29 (0)

0/28 (0)

0/26 (0)

0/27 (0)

1/27 (3.7)

2/28 (7.1)

3/28 (10.7)

2/28 (7.1)

0/28 (0)

0/27 (0)

Cotton wool(+)3

Docetaxel

1/113 (0.9)

2/104 (1.9)

2/104 (1.9)

2/100 (1.2)

1/84 (1.2)

1/38 (2.6)

2/31 (6.5)

6/82 (7.3)

4/64 (6.3)

2/57 (3.5)

Paclitaxel

0/31 (0)

3/33 (9.1)

1/29 (3.4)

5/29 (17.2)

0/28 (0)

2/18 (11.1)

1/13 (7.7)

7/25 (28)

7/20 (35)

2/14 (14.3)

Cisplatin/Carboplatin

0/65 (0)

1/55 (1.8)

0/48 (0.0)

0/43 (0)

0/16 (0)

0/8 (0)

0/3 (0)

1/29 (3.4)

2/26 (7.7)

0/19 0)

Oxaliplatin

0/27 (0)

3/25 (12.0)

3/25 (12)

5/22 (22.7)

3/16 (18.8)

2/12 (16.7)

8/20 (40)

3/16 (18.8)

1/12 (8.3)

1/12 (8.3)

Carboplatin+paclitaxel

0/49 (0)

6/36 (8.3)

4/35 (11.4)

8/36 (22.2)

6/29 (17.1)

4/27 (14.8)

1/20 (5)

6/33 (18.2)

4/31 (12.9)

0/16 (0)

Carboplatin+docetaxel

0/29 (0)

0/28 (0)

0/26 (0)

0/27 (0)

0/27 (0)

1/28 (3.6)

1/28 (3.6)

1/28 (3.6)

0/26 (0)

0/25 (0)

Monofilame-nt(+)3

Docetaxel

1/116 (0.9)

2/109 (1.8)

4/109 (3.7)

5/105 (4.8)

7/88 (8)

5/41 (12.2)

5/31 (16.1)

16/85 (18.8)

12/68 (17.6)

4/57 (7.0)

Paclitaxel

1/33 (3.0)

9/33 (27.3)

3/31 (9.7)

5/31 (16.1)

0/31 (0)

1/18 (5.6)

1/13 (7.7)

7/27 (25.9)

8/21 (38.1)

3/15 (20.0)

Cisplatin/Carboplatin

0/77 (0)

1/63 (1.6)

2/57 (3.5)

2/46 (4.3)

1/17 (5.9)

1/9 (0)

0/3 (0)

3/33 (9.1)

3/29 (10.3)

0/21 (0)

Oxaliplatin

0/28 (0)

2/26 (7.7)

3/25 (12)

4/22 (18.2)

2/22 (9.1)

3/16 (18.8)

1/11 (9.1)

7/21 (33.3)

4/17 (23.5)

1/12 (8.3)

Carboplatin+paclitaxel

0/49 (0)

4/43 (9.3)

6/42 (14.3)

11/42 (26.2)

11/38 (28.9)

9/30 (30)

4/20 (20)

10/38 (26.3)

7/35 (20)

2/17 (11.8)

Carboplatin+docetaxel

0/29 (0)

0/28 (0)

0/26 (0)

0/27 (0)

1/27 (3.7)

2/28 (7.1)

3/28 (10.7)

2/28 (7.1)

0/26 (0)

0/25 (0)

FACTGOG-Ntx

Numbness/tingling in hands 5

(>grade = 1)

Docetaxel

21/122 (17.2)

20/113 (17.7)

26/109 (23.9)

29/105 (27.6)

36/96 (37.5)

19/41 (46.3)

17/38 (44.7)

41/96 (42.7)

36/90 (40)

22/84 (26.2)

Paclitaxel

7/33 (21.2)

11/32 (34.4)

13/31 (41.9)

15/31 (41.9)

13/28 (48.4)

8/18 (44.4)

9/13 (69.2)

17/27 (63)

11/21 (52.4)

10/15 (66.7)

Cisplatin/Carboplatin

11/81 (13.6)

7/66 (10.6)

9/57 (15.8)

9/47 (19.1)

6/32 (18.7)

2/9 (22.2)

3/6 (50)

11/43 (25.6)

7/39 (17.9)

3/32 (9.4)

Oxaliplatin

2/28 (7.1)

10/24 (41.7)

15/26 (65.2)

15/20 (75)

15/20 (75)

8/14 (57.1)

5/9 (55.6)

15/21 (71.4)

11/17 (64.7)

10/12 (83.3)

Carboplatin+paclitaxel

5/50 (10)

23/44 (52.4)

25/41 (61.0)

22/41 (53.7)

22/37 (59.5)

18/28 (64.3)

13/25 (52)

22/40 (55)

16/40 (40)

8/25 (32)

Carboplatin+docetaxel

1/29 (3.4)

1/28 (3.6)

5/26 (19.2)

3/27 (11.1)

4/27 (14.8)

8/28 (28.6)

12/28 (42.9)

10/28 (35.7)

6/28 (21.4)

5/27 (18.5)

FACTGOG-Ntx Numbness/tingling in feet 5

(>grade = 1)

Docetaxel

6/122 (4.9)

10/113 (8.8)

12/109 (11)

22/105 (21)

29/96 (30.2)

12/41 (29.3)

9/38 (23.7)

37/96 (38.5)

31/90 (34.4)

21/84 (25.0)

Paclitaxel

5/32 (15.6)

11/31 (35.5)

13/31 (41.9)

15/31 (8.4)

14/28 (50)

8/18 (44.4)

7/13 (53.8)

16/27 (59.3)

10/21 (47.6)

7/15 (46.7)

Cisplatin/Carboplatin

5/81 (6.2)

7/66 (10.6)

5/57 (8.8)

7/47 (14.9)

7/32 (21.9)

3/9 (33.3)

3/6 (50)

14/43 (32.6)

8/39 (20.5)

2/32 (6.2)

Oxaliplatin

2/28 (7.2)

9/27 (37.5)

16/23 (69.6)

13/20 (65)

15/20 (75)

8/14 (57.1)

3/9 (33.3)

15/21 (71.4)

5/21 (23.8)

9/12 (75.0)

Carboplatin+paclitaxel

5/50 (10)

20/44 (45.5)

22/41 (53.7)

26/41 (63.4)

23/37 (62.2)

20/28 (71.4)

13/25 (52)

26/40 (75)

19/40 (47.5)

8/25 (32)

Carboplatin+docetaxel

1/29 (3.4)

2/28 (7.1)

4/26 (15.4)

5/27 (18.5)

6/27 (22.2)

8/28 (28.6)

13/28 (46.4)

10/28 (35.7)

6/28 (21.4)

5/27 (18.5)

ECIPN-20 (item 3) Numbness inhands/fingers 4

(> = grade 2)

Docetaxel

26/122 (21.3)

22/113 (19.5)

24/109 (22)

31/105 (29.5)

36/96 (37.5)

17/41 (41.5)

18/38 (47.4)

41/96 (42.7)

36/89 (40.4)

25/84 (29.8)

Paclitaxel

6/33 (18.2)

11/31 (35.5)

13/31 (41.9)

14/31 (45.2)

13/28 (46.4)

6/18 (33.3)

10/13 (76.9)

10/27 (59.3)

10/21 (47.6)

8/15 (53.3)

Cisplatin/Carboplatin

12/81 (14.8)

5/66 (7.6)

9/57 (15.8)

9/47 (19.1)

6/32 (18.7)

3/9 (33.3)

3/6 (50)

11/43 25.6)

8/39 (20.5)

4/32 (22.5)

Oxaliplatin

6/28 (21.4)

14/24 (58.8)

17/23 (73.9)

14/20 (70.0)

14/20 (70.0)

8/14 (57.1)

6/9 (66.6)

14/21 (66.7)

10/17 (38.1)

8/12 (66.7)

Carboplatin+paclitaxel

5/50 (10)

20/44 (45.5)

22/41 (53.7)

23/41 (56.1)

23/37 (62.2)

15/28 (53.6)

13/24 (54.2)

22/40 (55)

16/40 (40)

10/25 (40)

Carboplatin+docetaxel

2/29 (6.9)

2/28 (7.1)

4/26 (15.4)

4/27 (14.8)

4/27 (14.8)

7/28 (25)

11/28 (39.3)

9/28 (32.1)

7/28 (25)

6/27 (22.2)

ECIPN-20 (item 4) Numbness in feet/toes 4

(> = grade 2)

Docetaxel

8/122 (6.6)

12/113 (10.6)

15/109 (13.8)

23/105 (21.9)

30/96 (31.2)

10/41 (24.4)

11/38 (29.0)

37/96 (38.5)

31/90 (34.4)

24/84 (28.6)

Paclitaxel

7/33 (21.2)

12/32 (37.5)

11/31 (35.5)

11/31 (35.5)

14/28 (50.0)

9/18 (50.0)

8/13 (61.5)

15/27 (55.6)

 

6/15 (40)

Cisplatin/Carboplatin

8/81 (9.9)

4/66 (6.1)

6/57 (10.5)

7/47 (14.9)

5/32 (15.6)

3/9 (33.3)

3/6 (50)

11/43 (25.6)

9/39 (23.1)

3/32 (9.4)

Oxaliplatin

3/28 (10.7)

10/24 (41.7)

14/9 (60.1)

14/20 (70.0)

14/20 (70)

7/14 (50.0)

4/9 (44.4)

13/21 (61.9)

10/17 (58.8)

8/12 (66.7)

Carboplatin+paclitaxel

7/50 (14)

23/44 (52.3)

21/41951.2)

24/41 (58.5)

25/37 (67.6)

20/28 (71.4)

15/24 (62.5)

27/40 (67.5)

21/40 (52.5)

11/25 (440

Carboplatin+docetaxel

2/29 (6.9)

2/28 (7.1)

3/26 (11.5)

4/27 (14.8)

6/27 (22.2)

8/28 (28.6)

13/28 (46.4)

10/28 (35.7)

6/28 (21.4)

5/27 (18.5)

  1. 1NCI motor/sensory (>grade 2 = Moderate symptoms limiting instrumental ADL); 2 WHO CIPN (> = Grade 1 = Paresthesias and/or decreased tendon reflexes); 3 cotton wool/monofilament (+) = (abnormal sensation, a lot/a little/no sensation); 4 ECIPN-20 (> = grade 2 = A little); 5 FACTGOG-Ntx (> = 1 = a little bit)