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Fig. 5 | BMC Cancer

Fig. 5

From: Glucocorticoids promote the development of azoxymethane and dextran sulfate sodium-induced colorectal carcinoma in mice

Fig. 5

CORT feeding elevates expression of NF-κB and COX-2 in AOM/DSS-induced CRC in mouse. The colons of model mice with CT or VT (number = 6 per group) were processed for immunostaining of NF-κB and COX-2. Representative images of normal colorectal epithelia (Normal control) and neoplasms area, classified pathologically as adenoma with low grade dysplasia, adenoma with high grade dysplasia and ACA, stained with antibody of NF-κB p65 (a, at 20X), NF-κB P-p65 (b, at 20X) and their bar diagrams showing the percentages of NF-κB p65 and P-p65 (c) positive cells of different treatment groups. Representative images of normal colorectal epithelia (Normal control) and ACA area stained with antibody of COX-2 (d, at 20X and 40X). Data expressed as mean ± SD.*P<0.05, **P<0.01 by t-test for IHC data. ACA adenocarcinoma, IHC immunohistochemistry, CT CORT treatment, VT vehicle treatment

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