Fig. 4

CORT feeding elevates expression of proliferation marker in AOM/DSS-induced CRC mice. The colorectum of model mice with VT or CT (number = 3 per group) were processed for immunostaining of proliferation marker. Representative images of normal colorectal epithelia (Normal control) and neoplasms area, classified pathologically as adenoma with low grade dysplasia, adenoma with high grade dysplasia and ACA, stained with antibody of Ki-67 (a, at 20X), PCNA (b, at 20X) and their bar diagrams showing the percentages of Ki-67 and PCNA positive colonic epithelial cells (c). Data expressed as mean ± SD. **P<0.01 by unpaired t-test analysis. CT CORT treatment, VT vehicle treatment