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Table 2 Clinicopathological parameters, methylation and genetic alternations and its relation to ccRCC progression

From: DNA methylation associates with survival in non-metastatic clear cell renal cell carcinoma

  M0-PF (n = 64) M0-P (n = 23) M1 (n = 28) p-value all groups of patients p-value M0-PF vs. M0-P p-value M0-PF vs. M1 p-value M0-P vs. M1
Age (median ± SD) 68.5 ± 11.2 64.0 ± 12.7 63.5 ± 11.0 0.1031 0.165 0.0933 0.8573
Gender Male 34 11 21 0.0872 0.6632 0.0492 0.0462
Famale 30 12 7
Tumor diameter (mm) (median ± SD) 50.0 ± 30.7 90.0 ± 45.7 100.0 ± 35.7 < 0.0011 0.0013 < 0.0013 0.1073
Morphological grade G1 14 2 0 < 0.0012 0.0062 < 0.0012 0.1992
G2 31 8 7
G3 18 8 8
G4 1 5 12
T Stage T1 42 7 1 < 0.0012 0.0102 < 0.0012 0.0542
T2 11 6 8
T3 11 10 18
T4 0 0 1
TNM I 42 7 0 < 0.0012 0.0012 < 0.0012 < 0.0012
II 11 3 0
III 11 13 0
IV 0 0 28
Follow Up Status Alive 38 1 0 < 0.0012 < 0.0012 < 0.0012 0.1262
Alive, disease 0 4 1
Dead, ccRCC 0 18 27
Dead 26 0 0
Cluster A 57 13 11 < 0.0012 0.0012 < 0.0012 0.2202
B 7 10 17
PMC status Low 36 4 0.001
High 28 19
DM-CpGs, tot. Number (median ± SD) 9191 ± 4779 10,460 ± 3698 12,996 ± 4448 0.0011 0.2273 0.0053 0.1303
Hypermethylated CpGs (median ± SD) 5826 ± 2820 7617 ± 2990 8233 ± 448 0.0151 0.0253 0.0013 0.1503
Hypomethylated CpGs (median ± SD) 2810 ± 3173 2843 ± 2990 2688 ± 4249 0.9701 0.8103 0.9053 0.9103
Mitotic Age (median ± SD) 0.16 ± 0.05 0.18 ± 0.05 0.18 ± 0.06 0.0471 0.1323 0.0213 0.5383
Loss 1p WT 42 19 18 0.2722 0.1272 0.9012 0.1452
Loss 22 4 10
Loss 3p WT 11 3 4 0.2882 0.6432 0.7292 0.8982
Loss 53 20 24
Loss 3q WT 45 20 21 0.9952 0.1152 0.6462 0.2852
Loss 19 3 7
Gain 5q WT 30 11 13 0.0542 0.9382 0.9692 0.9212
Gain 34 12 15
Loss 6q WT 50 22 26 0.0272 0.0562 0.0862 0.6732
Loss 14 1 2
Gain 7p WT 51 21 17 0.0612 0.2062 0.0572 0.0132
Gain 13 2 11
Gain 7q WT 51 21 18 0.5982 0.2062 0.1162 0.0242
Gain 13 2 10
Loss 8p WT 47 15 18 0.0022 0.4552 0.3752 0.9452
Loss 17 8 10
Loss 9p WT 49 13 11 0.0022 0.0692 0.0012 0.2202
Loss 15 10 17
Loss 9q WT 51 13 11 0.0012 0.0312 < 0.0012 0.2202
Loss 13 10 17
Loss 10q WT 47 20 20 0.3612 0.1862 0.8422 0.1802
Loss 17 3 8
Loss 14q WT 48 13 15 0.0762 0.0972 0.0422 0.8332
Loss 16 10 13
Tot. number of alterations (median ± SD) 4 ± 2 4 ± 2 6 ± 3 0.1571 0.9343 0.0243 0.0503
  1. Differences between groups are compared using 1Kruskall-Wallis Test, 2χ2-test and 3Mann-Whitney Test
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