Fig. 6

Differently methylated CpG sites (CpGs) and its distribution over clear cell renal cell carcinoma (a) Bar-plot of number of hyper- (left panel) and hypomethylated (right panel) CpGs, within promoter regions of individual samples in the M0-PF, M0-P and M1 ccRCC groups. Inserted boxplots show number of hyper- and hypomethylated CpGs and its variation within the subgroups. Differences between groups were analysed using Mann-Whitney U-test. b Bar-plot for five ccRCC patients (number 1 through 6) represented by two to three pieces from the same tumor, showing the number of hypermethylated (left panel) and hypomethylated (right panel) promoter associated CpGs; c) PCA analysis of the first two principal components of the average methylation of promoter associated CpGs in multiple samples from five ccRCC patients. All samples are represented by a dot and each individual is highlighted according to legend in figure