Table 5 Comparison expressions level of TGF-β, IL-17, IL-6, IL-1, TNF-α, NF-κB, ROS, RNS, BRCA1 and BRCA2 in breast cancer, control samples, positive HPV, and negative HPV samples
From: Human papilloma virus and breast cancer: the role of inflammation and viral expressed proteins
Expression level | Breast Cancer (N = 72) | Control (N = 31) | Fold Change | Adjusted P-value* | HPV positive(N = 40) | HPV negative(N = 63) | Fold Change | Adjusted P-value* |
|---|---|---|---|---|---|---|---|---|
TGF-β | 12.40 ± 9.11 | 5.29 ± 3.68 | 2.34 | 0.0013 | 18.65 ± 7.53 | 4.94 ± 3.06 | 3.75 | 0.001 |
IL-17 | 12.61 ± 9.46 | 4.97 ± 4.29 | 2.54 | 0.0013 | 20.05 ± 6.28 | 4.13 ± 3.33 | 4.85 | 0.001 |
IL-6 | 9.32 ± 7.27 | 3.97 ± 3.29 | 2.35 | 0.0013 | 14.30 ± 5.58 | 3.52 ± 3.22 | 4.06 | 0.001 |
IL-1 | 8.90 ± 6.21 | 6.10 ± 4.48 | 1.46 | 0.0103 | 14.65 ± 5.06 | 3.87 ± 2.30 | 3.78 | 0.001 |
TNF-α | 9.40 ± 7.56 | 4.77 ± 3.28 | 1.97 | 0.0013 | 15.83 ± 6.33 | 3.05 ± 3.01 | 5.19 | 0.001 |
NF-κB | 9.26 ± 7.67 | 5.48 ± 4.91 | 1.69 | 0.0290 | 14.75 ± 5.97 | 3.92 ± 3.51 | 3.76 | 0.001 |
ROS | 10.08 ± 8.87 | 3.35 ± 3.06 | 3.01 | 0.0013 | 16.38 ± 7.29 | 2.78 ± 2.47 | 5.89 | < 0.001 |
RNS | 11.32 ± 9.84 | 3.94 ± 2.88 | 2.87 | 0.0013 | 17.82 ± 8.82 | 3.56 ± 2.83 | 5.01 | < 0.001 |
BRCA1 | 9.58 ± 5.35 | 14.45 ± 4.58 | 0.66 | 0.0013 | 8.32 ± 4.43 | 12.77 ± 5.58 | 0.65 | < 0.001 |
BRCA2 | 7.23 ± 3.84 | 12.66 ± 4.03 | 0.57 | 0.0013 | 5.15 ± 1.92 | 11.22 ± 3.79 | 0.46 | < 0.001 |