Fig. 5
From: CYR61 triggers osteosarcoma metastatic spreading via an IGF1Rβ-dependent EMT-like process
CYR61 controls the expression level of IGF1Rβ. a Immunohistochemical staining for IGF1Rβ in human samples derived from localized, metastatic or recurrent osteosarcoma. b Box plot of IHC staining score for IGF1Rβ in human samples. a: p < 0.05 vs. localized tumor. c Spearman correlation between IGF1Rβ expression levels and CYR61 expression levels in human samples. The black line shows the regression line. d Spearman correlation between IGF1Rβ expression levels and N-cadherin expression levels in human samples. The black line shows the regression line. e Immunohistochemical staining for IGF1Rβ in cell line-derived xenograft of control, CYR61 silenced or CYR61-overexpressing cells. f Box plot of IHC staining score for IGF1Rβ in murine samples. a: p < 0.05 vs. control cells