CYR61 controls the levels of N-cadherin in tumor tissues. (a) Immunohistochemical staining for N-cadherin and CYR61 of tissue microarray (TMA) containing human samples derived from localized, metastatic or recurrent osteosarcoma. No primary antibody verifies the specificity of the staining and lacked background noise. b, c Box plot of IHC staining score for CYR61 (b) and N cadherin (c). Results are expressed as arbitrary units (A.U.) (d) Spearman correlation between N-cadherin and CYR61 expression levels in human samples (n = 47). The black line shows the regression line. (e) Kaplan-Meier survival curves from patients with low CYR61 level or patients with highest CYR61 level.