Table 2 Difference in median OS and PFS between RCTs before and after 2012
| Â | DOX arm | Experimental arm | ||||
|---|---|---|---|---|---|---|
Before 2012 | After 2012 | p value | Before 2012 | After 2012 | p value | |
Median OS, month (95% CI) | 9.4 (8.4–12.0) | 14.5 (13.2–27.3) | 0.008 | 10.8 (9.0–11.7) | 16.3 (13.3–38.9) | 0.028 |
Median PFS, month (95% CI) | 5.1 (2.7–9.3) | 5.5 (4.6–6.1) | 0.951 | 4.0 (2.0–6.8) | 6.3 (2.8–8.3) | 0.135 |