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Table 4 Breast cancer related death and overall death in relation to statin use following breast cancer diagnosisa

From: Statin use and breast cancer survival – a Swedish nationwide study

  Breast cancer related death Overall death
Post-diagnostic statin use Events Person years HR 95% Confidence Intervals P-value Events Person years HR 95% Confidence Intervals P-value
Any statin use
 No (n = 20,503) 2245 86,856   3811 99,102    
 Yes (n = 4358) 412 17,715 0.83 0.75–0.93 0.001 848 21,340 0.89 0.82–0.96 0.003
Daily statin dose
 –           
 log (1 + ddd) (n = 93,595) 2657 10,4571b 0.93 0.91 – 0.95 < 0.001 4659 12,0442 0.96 0.95–0.97 < 0.001
Daily statin dose by solubility
 Lipophilic log(1 + ddd)    0.93 0.91–0.96 < 0.001    0.96 0.95–0.97 < 0.001
 Hydrophilic log(1 + ddd)    0.93 0.89–0.98 0.002    0.96 0.93–0.99 0.003
 Other log(1 + ddd)    0.99 0.84–1.17 0.93    1.07 0.97–1.16 0.24
  1. aThe Cox regression age at diagnosis, stage and diabetes took into account
  2. bIn the analysis of defined daily statin dose, the number of person years has been calculated for all subjects included without regard to treatment status. The same goes for the number of events