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Table 6 Results of the ROC analysis for uPA and PAI-1 and relevant events

From: Association of uPA and PAI-1 tumor levels and 4G/5G variants of PAI-1 gene with disease outcome in luminal HER2-negative node-negative breast cancer patients treated with adjuvant endocrine therapy

Characteristics uPA PAI-1
AUC ROCa (95% CI) 66.9% (50.9–82.9%) 67.32% (50.8–83.8%)
Likelihood ratio testb p = 0.0268 p = 0.0099
ROC-cut-off valuec 5.65 27.10
Sensitivity (95% CI) 60.0% (33.3–86.7%) 53.44% (26.7–80.0%)
Specificity (95% CI) 72.7% (62.1–83.3%) 81.82% (72.7–90.9%)
  1. aArea Under the ROC curve (DeLong’s method); bLikelihood ratio test for AUC ROC; cValue (ng/mg of protein) with maximum sensitivity and specificity