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Table 6 Results of the ROC analysis for uPA and PAI-1 and relevant events

From: Association of uPA and PAI-1 tumor levels and 4G/5G variants of PAI-1 gene with disease outcome in luminal HER2-negative node-negative breast cancer patients treated with adjuvant endocrine therapy

Characteristics

uPA

PAI-1

AUC ROCa (95% CI)

66.9% (50.9–82.9%)

67.32% (50.8–83.8%)

Likelihood ratio testb

p = 0.0268

p = 0.0099

ROC-cut-off valuec

5.65

27.10

Sensitivity (95% CI)

60.0% (33.3–86.7%)

53.44% (26.7–80.0%)

Specificity (95% CI)

72.7% (62.1–83.3%)

81.82% (72.7–90.9%)

  1. aArea Under the ROC curve (DeLong’s method); bLikelihood ratio test for AUC ROC; cValue (ng/mg of protein) with maximum sensitivity and specificity