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Table 4 The effects of classical prognostic factors on DFS, OS and EFS

From: Association of uPA and PAI-1 tumor levels and 4G/5G variants of PAI-1 gene with disease outcome in luminal HER2-negative node-negative breast cancer patients treated with adjuvant endocrine therapy

Characteristics DFS (months) OS (months) EFS (months)
Median (95% CI) Log-rank test Median (95% CI) Log-rank test Median (95% CI) Log-rank test
Tumor size
  ≤ 20 mm NR NR ns NR  
  > 20 - ≤ 30 mm NR 0.0082 NR   71 (> 71) 0.013
  > 30 mm 70 (> 38)   NR   70 (> 38)  
Tumor grade
 Grade 1 NR ns NR ns NR ns
 Grade 2/3 NR   NR   NR  
Estrogen receptor
  ≥ 50% NR ns NR ns NR ns
  < 50% NR 70 (> 70) 70 (> 70)
Ki67 index
  < 15% NR ns NR ns NR ns
  ≥ 15% NR NR NR
uPA and PAI-1 levels
 Both elevated NR (> 70)   NR   NR (> 70) ns
 One elevated NR ns NR ns NR
 Both normal NR (> 71)   NR   NR (> 71)
  1. NR-not reached; ns-not statistically significant