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Fig. 3 | BMC Cancer

Fig. 3

From: Programmed cell death ligand 1 (PD-L1, CD274) in cholangiocarcinoma – correlation with clinicopathological data and comparison of antibodies

Fig. 3

PD-L1 status in correlation with patient overall survival in cholangiocarcinoma subtypes. PD-L1 immunohistochemistry (clone SP263) results are correlated with overall survival of CCA patients, stratified by CCA subtypes. In intrahepatic CCA (iCCA), Kaplan-Meier curves show no significant overall patient survival difference in correlation with none vs any PD-L1 positivity in tumor cells (a), while significant decreased overall survival rates are seen in iCCA patients with PD-L1 positivity in > 5% of tumor cells (p = 0.024); (b)). In perihilar CCA (pCCA), Kaplan-Meier curves show no significant overall patient survival difference in correlation with none vs any PD-L1 positivity in tumor cells (c), while by trend decreased overall survival rates are in pCCA patients with PD-L1 positivity in > 5% of tumor cells (p = 0.060; (d)). PD-L1 positivity in distal CCA (dCCA) has no impact on overall patient survival in none vs any (e) or testing the cut-off of 5% (f)

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