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Table 1 Clinical and histological data of 58 patients with extraocular muscles metastases from BC. Literature review

From: Metastases to extraocular muscles from breast cancer: case report and up-to-date review of the literature

SOURCE AGE (YEARS) HISTOLOGY INVOLVED EOMs TREATMENTS OUTCOMES SURVIVAL
Wintersteiner H, [7] 58 NS Right MR, IR NS NS NS
Bedford and Daniel PD, [8] 72 NS All EOMs Bilaterally NT NS 12 Days
Ashton N, [9] 58 UNDIFFERENTIATED NS Wide Excision NS 2 Years and 6 Months
49 UNDIFFERENTIATED NS NS NS 6 Years
Stephen L, [10] NS NS MR Excision of the Mass NS NS
Thomas A, [11] 40 PD Left LR RT + CHT Growth on the lateral aspect completely regressed, no eyeball movement restriction. NS
Cuttone JM, [12] 62 NS Left LR NS NS NS
Mortada A, [13] 56 NS Right LR CHT + RT (40 Gy) NS 3 Years
55 NS Left MR CHT + RT (40 Gy) NS 3 Years
53 UNDIFFERENTIATED Left SR CHT + RT (40 Gy) NS 3 Years
Weiss R, [14] 66 Lobular Left MR NS NS NS
57 Lobular Left SR, LR NS NS NS
Citrin referred by Ashton N NS NS Right LR NS NS NS
Atlas SW, [15] NS NS Left MR NS NS NS
NS NS LR Bilaterally NS NS NS
Slavin ML, [16] 65 NS Right SO RT (30Gy) Subjective Diplopia and Objective Ophthalmoplegia abated within three months. NS
Goldberg RA, [17] NS NS NS NS NS NS
NS NS NS NS NS NS
Capone A, [18] 71 NS MR and LR Bilaterally Refused NS 23 Months
Glazer LC, [19] 64 NS Right MR, Left MR, LR Tamoxifen + RT (35Gy) + CHT No response, more advanced periocular infiltration bilaterally, metastases to multiple body sites. NS
Van der Herjden A, [20] 47 Lobular Right IR and IO NS NS NS
Toller KK, [21] 47 Lobular All EOMs Bilaterally Right Anterior Orbitotomy. RT and CHT refused. Unchanged 9 Months
Lacey B, [4] NS Lobular MR and IR Bilaterally NS NS NS
NS NS NS NS NS NS
NS NS NS NS NS NS
Wallace DK, [22] 79 NS Left MR Orbital Surgery No diplopia in primary gaze or reading position. NS
Lell M, [23] 63 Lobular MR, SR and SO Bilaterally NS NS NS
Fenton S, [24] 53 NS LR RT Full recovery?? NS
Spitzer SG, [25] 75 PD All EOMs Bilaterally CHT + RT (30 Gy) + Letrozole Improvement in ocular motility except for limited abduction. NS
Peckham EL, [26] 52 PD All EOMs Bilaterally NS NS NS
Luneau K, [27] 45 NS NS NS NS NS
Kouvaris JR, [28] 50 Lobular All EOMs bilaterally. RT (47.5 Gy) + Anastrozole + CHT (vinorelbine and mitomycin) + Local Hyperthermia. Diplopia partial amelioration. 13 Months.
Milman T, [29] 83 Ductal Right LR, MR, SR; Letrozole Partial improvement in ocular motility. NS
Left IO, IR
Valenzuela AA, [30] NS NS NS NS NS NS
NS NS NS NS NS NS
NS NS NS NS NS NS
NS NS NS NS NS NS
NS NS NS NS NS NS
NS NS NS NS NS NS
Murthy R, [31] 61 Lobular Right SR, LR, IR; RT (54 Gy) + Tamoxifen Complete resolution at TC/PET, improvement of the ocular motility and resolution of diplopia but mild bilateral ptosis. NS
Left SR
Wiggings RE, [32] 49 NS Right IR RT + CHT Partial Improvement 11 months
45 NS Four Recti Bilaterally Right SO RT + CHT Partial Improvement 8 months
Magliozzi P, [33] NS Undifferentiated IR NS NS NS
Sharma V, [34] 43 Ductal IR, LR RT Improvement NS
Khan NA, [35] NS Ductal Right LR; Whole Brain RT Partial Response Alive
Left IR, LR
Amer NM, [36] 66 Ductal Four Recti Unilaterally Anastrozol + RT (35–40 Gy) NS NS
Pierson TM, [37] NS NS NS NS NS NS
NS NS NS NS NS NS
NS NS NS NS NS NS
NS NS NS NS NS NS
NS NS NS NS NS NS
NS NS NS NS NS NS
Homer N, [38] 47 Lobular MR NS NS NS
63 Lobular NS NS NS NS
67 Lobular MR, LR NS NS NS
68 Not biopsied Right LR, IR NS NS NS
64 Lobular Rectus Muscle NS NS NS
Current Study 51 Ductal IR RT (40 Gy) + Fulvestrant+Palbociclib. Total regression of the orbital lesion at PET/TC without improvement in eyesight. Alive
  1. LEGEND – EOM ExtraOcular Muscle, NS Not Specified, PD Poorly Differentiated, MR Medial Rectus, SR Superior Rectus, LR Lateral Rectus, IR Inferior Rectus, SO Superior Oblique, IO Inferior Oblique, NT No Treatment, RT Radiotherapy, CHT Chemiotherapy