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Table 1 Summary of the studies included in the systematic review and meta-analysis

From: Prophylactic cranial irradiation in small cell lung cancer: a systematic review and meta-analysis

Study Age Gender (male %) Brain scan Complete Response (%) Extent of disease Median FU (year) PCI schedule (Gy/fraction) N. of patients
         PCI No PCI    
  PCI No PCI PCI No PCI   PCI No PCI LD % ED % LD % ED %    
Takahashi et al., 2017 69 (43–83) 69 (37–86) 84 88 yes 15 14 0 100 0 100 1 25/10 224
Schild et al., 2012 63 (34–79) 63 (37–80) 57 60 no NC NC 73 27 31 69 6 30/15; 25/10 739
Slotman et al., 2007 63 (37–75) 63 (39–75) 68 57 no NC NC 0 100 0 100 0.8 20–30/5–12 286
Laplanche et al., 1998 58 ± 8 57 ± 9 89 92 yes 100 83 17 86 14 5 24–30/8–15 211
Gregor et al., 1997 60 (37–79) 61 (28–76) 64 62 no 100 100 0 100 0 42 8–38/1–18 314
Arriagada et al., 1995 56 ± 9 57 ± 8 88 86 yes 100 83 17 79 21 8.3 24/8 294
Ohonoshi et al., 1993 62 (43–75) 66 (45–79) 65 83 yes 100 61 39 70 30 7.5 40/20 46
  1. PCI prophylactic cranial irradiation, FU follow up, N number, NC not clear, LD limited disease, ED extensive disease
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