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Fig. 4 | BMC Cancer

Fig. 4

From: Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional BRCA1

Fig. 4

Pre-treatment with PARPi followed by cisplatin increases cell death. SKOV3 (a) and (b) and SNU-251 (a) and (c) cells were treated with different combinations of olaparib and cisplatin for 48 h, then apoptotic rates were assessed using Annexin V/PI double staining followed by flow cytometry analysis. d Protein expression of pro and anti-apoptotic proteins (Bcl2, p-Bcl, Bcl-XL, Bad, p-Bad, cleaved caspase3) were examined by western blot in SKOV3 and SNU-251 cells. Results are presented as means ± SEM for triplicates of three independent experiments,*p value < 0.05

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