Table 2 Prognostic significance of the 16 selected genes in the HNC patients
No. | Gene | P -value | Hazard ratio (CI) | Pathway |
|---|---|---|---|---|
4 | IGF1R | 0.03497 | 1.57 (1.03–2.41) | Focal adhesion HIF-1 signaling pathway PI3K-Akt signaling pathway Pluripotency of stem cells |
3 | VEGFA | 0.14780 | 1.31 (0.91–1.88) | Focal adhesion HIF-1 signaling pathway PI3K-Akt signaling pathway |
2 | LAMC2 | 0.00228 | 1.97 (1.26–3.07) | Focal adhesion PI3K-Akt signaling pathway |
2 | ITGA6 | 0.00514 | 1.76 (1.10–2.64) | Focal adhesion PI3K-Akt signaling pathway |
2 | ITGB1 | 0.01010 | 1.80 (1.14–2.83) | Focal adhesion PI3K-Akt signaling pathway |
2 | ITGB4 | 0.01463 | 1.57 (1.09–2.27) | Focal adhesion PI3K-Akt signaling pathway |
2 | LAMA3 | 0.01549 | 1.69 (1.10–2.60) | Focal adhesion PI3K-Akt signaling pathway |
2 | IL6 | 0.01611 | 1.57 (1.08–2.28) | HIF-1 signaling pathway PI3K-Akt signaling pathway |
1 | DDIT4 | 0.00002 | 2.45 (1.61–3.72) | PI3K-Akt signaling pathway |
1 | JARID2 | 0.00212 | 1.91 (1.26–2.91) | Pluripotency of stem cells |
1 | SLC2A1 | 0.00421 | 2.17 (1.26–3.73) | HIF-1 signaling pathway |
1 | ENO2 | 0.00447 | 1.69 (1.17–2.44) | HIF-1 signaling pathway |
1 | FZD10 | 0.03798 | 1.71 (1.02–2.87) | Pluripotency of stem cells |
1 | MYL9 | 0.07662 | 0.65 (0.41–1.05) | Focal adhesion |
1 | FLNB | 0.12240 | 1.33 (0.92–1.93) | Focal adhesion |
1 | SGK1 | 0.03847 | 1.64 (1.02–2.63) | PI3K-Akt signaling pathway |