Table 1 List of up-regulated genes enriched in the four core molecular pathways

Focal adhesion

FLNA, FLNB^a, GSK3B, IGF1R^a, ITGA6^a, ITGB1^a, ITGB4^a, LAMA3^a, LAMC2^a, MYL9^a, VEGFA^a

PI3K-Akt signaling pathway

DDIT4^a, GNG4, EFNA1, FGFR3, GSK3B, IGF1R^a, ITGA6^a, ITGB1^a, ITGB4^a, IL6^a, LAMA3^a, LAMC2^a, SGK1^a, VEGFA^a

HIF-1 signaling pathway

ENO2^a, IGF1R^a, IL6^a, SLC2A1^a, VEGFA^a

Pluripotency of stem cells

FGFR3, FZD10^a, GSK3B, IGF1R^a, JARID2^a