TY - JOUR AU - Plum, Patrick Sven AU - Gebauer, Florian AU - Krämer, Max AU - Alakus, Hakan AU - Berlth, Felix AU - Chon, Seung-Hun AU - Schiffmann, Lars AU - Zander, Thomas AU - Büttner, Reinhard AU - Hölscher, Arnulf Heinrich AU - Bruns, Christiane Josephine AU - Quaas, Alexander AU - Loeser, Heike PY - 2019 DA - 2019/01/08 TI - HER2/neu (ERBB2) expression and gene amplification correlates with better survival in esophageal adenocarcinoma JO - BMC Cancer SP - 38 VL - 19 IS - 1 AB - HER2 (ERBB2 or HER2/neu) is a tyrosine-kinase increasing cell proliferation. Overexpression/amplification of HER2 is correlated with worse prognosis in solid malignancies. Consequently, HER2 targeting is established in breast and upper gastrointestinal tract cancer. There are conflicting data concerning the impact of HER2 overexpression on esophageal adenocarcinoma (EAC), as most studies do not differ between cancers of the esophagus/gastroesophageal junction and the stomach. The aim of this study was to analyze the expression/amplification of HER2 in EAC in correlation to clinicopathological data to verify its prognostic impact. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-018-5242-4 DO - 10.1186/s12885-018-5242-4 ID - Plum2019 ER -