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Table 5 The relationship of seven 3′UTR polymorphisms with lung cancer according to the histology stratification

From: Single nucleotide polymorphism in the 3′ untranslated region of LPP is a risk factor for lung cancer: a case-control study

SNP ID Model Genotype Control Adenocarcinoma Squamous cell carcinoma Small cell carcinoma
Case OR (95% CI) p–value Case OR (95% CI) p–value Case OR (95% CI) p–value
rs1064607 Allele G 488 (63.5%) 169 (56.3%) 1.00 0.030 121 (62.7%) 1.00 0.762 92 (62.2%) 1.00 0.750
C 280 (36.5%) 131 (43.7%) 1.35 (1.03–1.77) 73 (37.6%) 1.05 (0.76–1.46) 56 (37.8%) 1.06 (0.74–1.53)
Codominant G/G 157 (40.9%) 47 (31.3%) 1.00 0.085 37 (38.1%) 1.00 0.760 27 (36.5%) 1.00 0.780
G/C 174 (45.3%) 75 (50%) 1.39 (0.89–2.16) 47 (48.5%) 1.22 (0.72–2.07) 38 (51.4%) 1.20 (0.69–2.10)
C/C 53 (13.8%) 28 (18.7%) 1.90 (1.06–3.42) 13 (13.4%) 1.13 (0.52–2.47) 9 (12.2%) 0.99 (0.43–2.31)
Dominant G/G 157 (40.9%) 47 (31.3%) 1.00 0.053 37 (38.1%) 1.00 0.480 27 (36.5%) 1.00 0.590
G/C-C/C 227 (59.1%) 103 (68.7%) 1.50 (0.99–2.28) 60 (61.9%) 1.20 (0.73–1.98) 47 (63.5%) 1.16 (0.68–1.97)
Recessive G/G-G/C 331 (86.2%) 122 (81.3%) 1.00 0.096 84 (86.6%) 1.00 0.970 65 (87.8%) 1.00 0.780
C/C 53 (13.8%) 28 (18.7%) 1.57 (0.93–2.66) 13 (13.4%) 1.02 (0.49–2.10) 9 (12.2%) 0.89 (0.41–1.95)
Log-additive 1.38 (1.04–1.83) 0.026 1.10 (0.77–1.58) 0.590 1.05 (0.72–1.53) 0.810
  1. SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval. p values were adjusted by gender and age
  2. Bold indicates statistical signifcance (p < 0.05)