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Table 4 The relationship of seven 3′UTR polymorphisms with lung cancer according to the stratification by gender adjusted by gender + age

From: Single nucleotide polymorphism in the 3′ untranslated region of LPP is a risk factor for lung cancer: a case-control study

SNP ID Model Genotype Male Female
Control Case Adjusted analysis Crude analysis Control Case Adjusted analysis Crude analysis
OR (95%CI) p OR (95%CI) p OR (95%CI) p OR (95%CI) p
rs1064607 Allele G 358 (64.4%) 286 (58.6%) 1.00 0.055    130 (61.3%) 96 (62.3%) 1.00 0.840   
C 198 (35.6%) 202 (41.4%) 1.28 (0.99–1.64)    82 (38.7%) 58 (37.7%) 0.96 (0.62–1.47)   
Codominant G/G 118 (42.5%) 78 (32%) 1.00 0.078 1.00   39 (36.8%) 33 (42.9%) 1.00 0.370 1.00  
G/C 122 (43.9%) 130 (53.3%) 1.58 (1.04–2.39) 1.61 (1.10–2.35) 0.043 52 (49.1%) 30 (39%) 0.68 (0.35–1.30) 0.68 (0.36–1.30) 0.390
C/C 38 (13.7%) 36 (14.8%) 1.54 (0.85–2.80) 1.43 (0.84–2.45)   15 (14.2%) 14 (18.2%) 1.12 (0.47–2.68) 1.10 (0.47–2.62)  
Dominant G/G 118 (42.5%) 78 (32%) 1.00 0.024 1.00 0.013 39 (36.8%) 33 (42.9%) 1.00 0.410 1.00 0.410
G/C-C/C 160 (57.5%) 166 (68%) 1.57 (1.06–2.33) 1.57 (1.10–2.25) 67 (63.2%) 44 (57.1%) 0.77 (0.42–1.42) 0.78 (0.43–1.41)
Recessive G/G-G/C 240 (86.3%) 208 (85.2%) 1.00 0.530 1.00 0.720 91 (85.8%) 63 (81.8%) 1.00 0.440 1.00 0.460
C/C 38 (13.7%) 36 (14.8%) 1.19 (0.69–2.05) 1.09 (0.67–1.79) 15 (14.2%) 14 (18.2%) 1.38 (0.62–3.08) 1.35 (0.61–2.99)
Log-additive 1.32 (1.00–1.74) 0.053 1.29 (1.00–1.66) 0.052 0.96 (0.63–1.47) 0.870 0.96 (0.63–1.46) 0.850
rs3796283 Allele A 332 (59.7%) 263 (53.9%) 1.00 0.058    118 (55.7%) 92 (59.7%) 1.00 0.440   
G 224 (40.3%) 225 (46.1%) 1.27 (0.99–1.62)    94 (44.3%) 62 (40.3%) 0.85 (0.56–1.29)   
Codominant A/A 104 (37.4%) 64 (26.2%) 1.00 0.036 1.00   30 (28.3%) 30 (39%) 1.00 0.160 1.00  
G/A 124 (44.6%) 135 (55.3%) 1.76 (1.14–2.71) 1.77 (1.19–2.63) 0.017 58 (54.7%) 32 (41.6%) 0.52 (0.27–1.03) 0.55 (0.28–1.07) 0.190
G/G 50 (18%) 45 (18.4%) 1.43 (0.81–2.50) 1.46 (0.88–2.43)   18 (17%) 15 (19.5%) 0.80 (0.34–1.89) 0.83 (0.36–1.95)  
Dominant A/A 104 (37.4%) 64 (26.2%) 1.00 0.014 1.00 0.006 30 (28.3%) 30 (39%) 1.00 0.100 1.00 0.130
G/A-G/G 174 (62.6%) 180 (73.8%) 1.67 (1.10–2.51) 1.68 (1.16–2.45) 76 (71.7%) 47 (61%) 0.59 (0.31–1.11) 0.62 (0.33–1.15)
Recessive A/A-G/A 228 (82%) 199 (81.6%) 1.00 0.980 1.00 0.890 88 (83%) 62 (80.5%) 1.00 0.680 1.00 0.660
G/G 50 (18%) 45 (18.4%) 1.01 (0.61–1.65) 1.03 (0.66–1.61) 18 (17%) 15 (19.5%) 1.17 (0.55–2.52) 1.18 (0.55–2.53)
Log-additive 1.26 (0.96–1.66) 0.095 1.27 (0.99–1.63) 0.056 0.83 (0.54–1.27) 0.380 0.84 (0.55–1.29) 0.430
rs2378456 Allele G 312 (56.3%) 245 (50.8%) 1.00 0.077    107 (50.5%) 88 (58.7%) 1.00 0.120   
C 242 (43.7%) 237 (49.2%) 1.25 (0.98–1.59)    105 (49.5%) 62 (41.3%) 0.72 (0.47–1.09)   
Codominant G/G 93 (33.6%) 58 (24.1%) 1.00 0.100 1.00   24 (22.6%) 30 (40%) 1.00 0.022 1.00  
G/C 126 (45.5%) 129 (53.5%) 1.63 (1.04–2.56) 1.64 (1.09–2.47) 0.053 59 (55.7%) 28 (37.3%) 0.37 (0.18–0.76) 0.38 (0.19–0.76) 0.023
C/C 58 (20.9%) 54 (22.4%) 1.39 (0.80–2.40) 1.49 (0.91–2.45)   23 (21.7%) 17 (22.7%) 0.60 (0.26–1.38) 0.59 (0.26–1.35)  
Dominant G/G 93 (33.6%) 58 (24.1%) 1.00 0.041 1.00 0.017 24 (22.6%) 30 (40%) 1.00 0.012 1.00 0.012
G/C-C/C 184 (66.4%) 183 (75.9%) 1.55 (1.02–2.38) 1.59 (1.08–2.35) 82 (77.4%) 45 (60%) 0.44 (0.23–0.84) 0.44 (0.23–0.84)
Recessive G/G-G/C 219 (79.1%) 187 (77.6%) 1.00 0.940 1.00 0.690 83 (78.3%) 58 (77.3%) 1.00 0.830 1.00 0.880
C/C 58 (20.9%) 54 (22.4%) 1.02 (0.64–1.62) 1.09 (0.72–1.66) 23 (21.7%) 17 (22.7%) 1.08 (0.53–2.22) 1.06 (0.52–2.15)
Log-additive 1.21 (0.92–1.58) 0.180 1.25 (0.97–1.59) 0.078 0.73 (0.48–1.11) 0.140 0.72 (0.48–1.10) 0.130
  1. OR odds ratio, 95% CI 95% confidence interval
  2. Bold indicates statistical signifcance (p < 0.05)