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Table 3 Sensitivity and specificity of PET-CT using different maximum SUV cutoffs for the staging of the mediastinal lymph nodes (per-patient and per-nodal-station)

From: PET-CT has low specificity for mediastinal staging of non-small-cell lung cancer in an endemic area for tuberculosis: a diagnostic test study (LACOG 0114)

Cut-off Measure Hour 1 (Per-Patient) Hour 2 (Per-Patient) Hour 1 (Per-Nodal-Station)
SUV_Maxa >  0 Sensitivity 0.87 (0.66–0.97) 0.87 (0.66–0.97) 0.66 (0.49–0.80)
Specificity 0.45 (0.33–0.58) 0.44 (0.31–0.57) 0.74 (0.66–0.80)
Positive Predictive Value 0.37 (0.31–0.44) 0.36 (0.30–0.43) 0.35 (0.28–0.43)
Negative Predictive Value 0.90 (0.76–0.97) 0.90 (0.75–0.96) 0.91 (0.86–0.94)
SUV_Maxa ≥ 2.5 Sensitivity 0.78 (0.56–0.93) 0.83 (0.61–0.95) 0.61 (0.43–0.76)
Specificity 0.52 (0.39–0.65) 0.52 (0.39–0.65) 0.77 (0.70–0.83)
Positive Predictive Value 0.38 (0.30–0.46) 0.39 (0.32–0.47) 0.37 (0.28–0.46)
Negative Predictive Value 0.87 (0.74–0.94) 0.89 (0.76–0.95) 0.90 (0.86–0.93)
SUV_Maxa ≥ 3 Sensitivity 0.70 (0.47–0.87) 0.78 (0.56–0.93) 0.55 (0.38–0.71)
Specificity 0.61 (0.48–0.73) 0.58 (0.45–0.71) 0.82 (0.75–0.87)
Positive Predictive Value 0.40 (0.31–0.50) 0.41 (0.33–0.50) 0.40 (0.30–0.50)
Negative Predictive Value 0.84 (0.74–0.91) 0.88 (0.76–0.94) 0.89 (0.85–0.92)
SUV_Maxa ≥ 5 Sensitivity 0.65 (0.43–0.84) 0.70 (0.47–0.87) 0.47 (0.31–0.64)
Specificity 0.79 (0.67–0.88) 0.71 (0.58–0.82) 0.91 (0.86–0.95)
Positive Predictive Value 0.54 (0.40–0.67) 0.47 (0.36–0.59) 0.55 (0.40–0.68)
Negative Predictive Value 0.86 (0.78–0.92) 0.86 (0.77–0.92) 0.89 (0.85–0.92)
SUV_Maxa ≥ SUV Liver Sensitivity 0.78 (0.56–0.93) 0.82 (0.60–0.95)
Specificity 0.62 (0.48–0.74) 0.58 (0.44–0.70)
Positive Predictive Value 0.44 (0.35–0.54) 0.42 (0.34–0.51)
Negative Predictive Value 0.88 (0.77–0.94) 0.90 (0.77–0.96)
  1. aSUV_Max: Maximum value of SUV uptake between 2R, 2 L, 4R, 4 L, 7 and aortopulmonary when evaluating per-patient, and 2R, 2 L, 2R, 4 L and 7 when evaluating per-nodal-station