Table 3 Sensitivity and specificity of PET-CT using different maximum SUV cutoffs for the staging of the mediastinal lymph nodes (per-patient and per-nodal-station)
Cut-off | Measure | Hour 1 (Per-Patient) | Hour 2 (Per-Patient) | Hour 1 (Per-Nodal-Station) |
|---|---|---|---|---|
SUV_Maxa > 0 | Sensitivity | 0.87 (0.66–0.97) | 0.87 (0.66–0.97) | 0.66 (0.49–0.80) |
Specificity | 0.45 (0.33–0.58) | 0.44 (0.31–0.57) | 0.74 (0.66–0.80) | |
Positive Predictive Value | 0.37 (0.31–0.44) | 0.36 (0.30–0.43) | 0.35 (0.28–0.43) | |
Negative Predictive Value | 0.90 (0.76–0.97) | 0.90 (0.75–0.96) | 0.91 (0.86–0.94) | |
SUV_Maxa ≥ 2.5 | Sensitivity | 0.78 (0.56–0.93) | 0.83 (0.61–0.95) | 0.61 (0.43–0.76) |
Specificity | 0.52 (0.39–0.65) | 0.52 (0.39–0.65) | 0.77 (0.70–0.83) | |
Positive Predictive Value | 0.38 (0.30–0.46) | 0.39 (0.32–0.47) | 0.37 (0.28–0.46) | |
Negative Predictive Value | 0.87 (0.74–0.94) | 0.89 (0.76–0.95) | 0.90 (0.86–0.93) | |
SUV_Maxa ≥ 3 | Sensitivity | 0.70 (0.47–0.87) | 0.78 (0.56–0.93) | 0.55 (0.38–0.71) |
Specificity | 0.61 (0.48–0.73) | 0.58 (0.45–0.71) | 0.82 (0.75–0.87) | |
Positive Predictive Value | 0.40 (0.31–0.50) | 0.41 (0.33–0.50) | 0.40 (0.30–0.50) | |
Negative Predictive Value | 0.84 (0.74–0.91) | 0.88 (0.76–0.94) | 0.89 (0.85–0.92) | |
SUV_Maxa ≥ 5 | Sensitivity | 0.65 (0.43–0.84) | 0.70 (0.47–0.87) | 0.47 (0.31–0.64) |
Specificity | 0.79 (0.67–0.88) | 0.71 (0.58–0.82) | 0.91 (0.86–0.95) | |
Positive Predictive Value | 0.54 (0.40–0.67) | 0.47 (0.36–0.59) | 0.55 (0.40–0.68) | |
Negative Predictive Value | 0.86 (0.78–0.92) | 0.86 (0.77–0.92) | 0.89 (0.85–0.92) | |
SUV_Maxa ≥ SUV Liver | Sensitivity | 0.78 (0.56–0.93) | 0.82 (0.60–0.95) | – |
Specificity | 0.62 (0.48–0.74) | 0.58 (0.44–0.70) | – | |
Positive Predictive Value | 0.44 (0.35–0.54) | 0.42 (0.34–0.51) | – | |
Negative Predictive Value | 0.88 (0.77–0.94) | 0.90 (0.77–0.96) | – |