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Table 3 Uni- and multi-variable Cox regressions of factors associated with biochemical recurrence

From: Risk of biochemical recurrence based on extent and location of positive surgical margins after robot-assisted laparoscopic radical prostatectomy

  Univariable Multivariable
HR 95% CI p-value HR 95% p-value
Age 1.03 (1.01–1.06) 0.015  
Preop PSA 1.02 (1.01–1.03) < 0.001  
Year of treatment 1.10 (1.02–1018) 0.012  
Pathological Gleason Score
 ≤6 REF    REF   
 3 + 4 3.36 (2.00–5.64) < 0.001 2.86 (1.68–4.88) < 0.001
 4 + 3 7.21 (4.13–12.60) < 0.001 3.88 (2.12–7.07) < 0.001
 ≥8 13.75 (7.96–23.74) < 0.001 7.97 (4.38–14.51) < 0.001
Stage pT
 pT2 REF    REF   
 pT3a 3.12 (2.06–4.73) < 0.001 2.28 (1.48–3.52) < 0.001
 pT3b & pT4a 7.37 (4.89–11.12) < 0.001 3.07 (1.93–4.90) < 0.001
 Involvment of lymph nodes 8.84 (4.57–17.12) < 0.001 3.42 (1.70–6.91) < 0.001
Apical margins
 focal 1.10 (0.63–1.92) 0.742 0.86 (0.49–1.50) 0.586
 extensive 3.80 (2.13–6.77) < 0.001 2.62 (1.40–4.90) 0.003
Posterolateral margins
 focal 2.59 (1.62–4.14) < 0.001  
 extensive 2.73 (1.46–5.08) 0.002  
Base margins
 focal 2.60 (1.40–4.84) 0.003  
 extensiveb 1.45 (0.46 – 4.58) 0.525  
Neck margins
 focal 1.55 (0.21–10.98) 0.67  
 extensivec
  1. aOnly 2 patients were at stage pT4, both of which had biochemical recurrence
  2. bOnly 7 patients had extensive base margins, 3 of which had biochemical recurrence
  3. cNone of the patients had extensive neck margins