Table 2 Extent of Exposure: Number of cycles, treatment duration and total dose of BIBW 2992 (Safety Population)
|  | Dose level 1 | Dose level − 1 | Total |
|---|---|---|---|
Variable | (N = 3) | (N = 6) | (N = 9) |
Number of cycles of chemotherapy | |||
 N | 3 | 6 | 9 |
 Mean (SD) | 5.33 (2.89) | 4.50 (2.81) | 4.78 (2.68) |
 Min | 2.0 | 2.0 | 2.0 |
 Median | 7.00 | 3.50 | 4.00 |
 Max | 7.0 | 8.0 | 8.0 |
 Missing | 0 | 0 | 0 |
Duration of BIBW Treatment [months] | |||
 N | 3 | 6 | 9 |
 Mean (SD) | 4.0 (2.5) | 3.3 (2.3) | 3.6 (2.2) |
 Min | 1.3 | 0.8 | 0.8 |
 Median | 4.4 | 2.7 | 3.3 |
 Max | 6.3 | 6.1 | 6.3 |
 Missing | 0 | 0 | 0 |
Total number of BIBW 2992 doses | |||
 N | 3 | 6 | 9 |
 Mean (SD) | 114.33 (53.50) | 94.17 (67.54) | 100.89 (60.57) |
 Min | 54.0 | 9.0 | 9.0 |
 Median | 133.00 | 75.00 | 79.00 |
 Max | 156.0 | 179.0 | 179.0 |
 Missing | 0 | 0 | 0 |