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Table 1 IC50 values of shikonin and analogues for inhibition of recombinant human protein phosphatases

From: Shikonin inhibits cancer cell cycling by targeting Cdc25s

Structure R Name Cdc25A (μM) Cdc25B (μM) Cdc25C (μM)
-OH Shikonin 2.14 ± 0.21 5.82 ± 0.37 4.78 ± 0.18
-H Deoxyshikonin 3.22 ± 0.76 7.32 ± 0.45 6.33 ± 0.65
-OCOCH3 Acetylshikonin 3.92 ± 0.66 3.87 ± 0.68 4.67 ± 0.34
-OCOCH(CH3)2 Isobutylshikonin 6.79 ± 1.02 7. 86 ± 0.23 5.89 ± 0.43
-OCOCH2CH(CH3)2 Isovalerylshikonin 9.53 ± 0.78 11. 23 ± 1.22 10.98 ± 0.97
-OCOCH=CH(CH3)2 β,β-Dimethylacrylshikonin 4.67 ± 0.85 8.56 ± 0.67 10. 58 ± 1.13
-OCOCH(CH3)CH2CH3 α-Methyl-η-butylshikonin 11.24 ± 1.45 14.32 ± 1.27 13.45 ± 1.45
  1. All values are micromolar concentrations and are the mean ± S.E.M. of three or more independent determinations