From: Shikonin inhibits cancer cell cycling by targeting Cdc25s
Structure | R | Name | Cdc25A (μM) | Cdc25B (μM) | Cdc25C (μM) |
---|---|---|---|---|---|
-OH | Shikonin | 2.14 ± 0.21 | 5.82 ± 0.37 | 4.78 ± 0.18 | |
-H | Deoxyshikonin | 3.22 ± 0.76 | 7.32 ± 0.45 | 6.33 ± 0.65 | |
-OCOCH3 | Acetylshikonin | 3.92 ± 0.66 | 3.87 ± 0.68 | 4.67 ± 0.34 | |
-OCOCH(CH3)2 | Isobutylshikonin | 6.79 ± 1.02 | 7. 86 ± 0.23 | 5.89 ± 0.43 | |
-OCOCH2CH(CH3)2 | Isovalerylshikonin | 9.53 ± 0.78 | 11. 23 ± 1.22 | 10.98 ± 0.97 | |
-OCOCH=CH(CH3)2 | β,β-Dimethylacrylshikonin | 4.67 ± 0.85 | 8.56 ± 0.67 | 10. 58 ± 1.13 | |
-OCOCH(CH3)CH2CH3 | α-Methyl-η-butylshikonin | 11.24 ± 1.45 | 14.32 ± 1.27 | 13.45 ± 1.45 |