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Table 1 IC50 values of shikonin and analogues for inhibition of recombinant human protein phosphatases

From: Shikonin inhibits cancer cell cycling by targeting Cdc25s

Structure

R

Name

Cdc25A (μM)

Cdc25B (μM)

Cdc25C (μM)

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-OH

Shikonin

2.14 ± 0.21

5.82 ± 0.37

4.78 ± 0.18

-H

Deoxyshikonin

3.22 ± 0.76

7.32 ± 0.45

6.33 ± 0.65

-OCOCH3

Acetylshikonin

3.92 ± 0.66

3.87 ± 0.68

4.67 ± 0.34

-OCOCH(CH3)2

Isobutylshikonin

6.79 ± 1.02

7. 86 ± 0.23

5.89 ± 0.43

-OCOCH2CH(CH3)2

Isovalerylshikonin

9.53 ± 0.78

11. 23 ± 1.22

10.98 ± 0.97

-OCOCH=CH(CH3)2

β,β-Dimethylacrylshikonin

4.67 ± 0.85

8.56 ± 0.67

10. 58 ± 1.13

-OCOCH(CH3)CH2CH3

α-Methyl-η-butylshikonin

11.24 ± 1.45

14.32 ± 1.27

13.45 ± 1.45

  1. All values are micromolar concentrations and are the mean ± S.E.M. of three or more independent determinations