High Oct4 expression: implications in the pathogenesis of neuroblastic tumours

BMC Cancer

Table 1 Statistically significant clinical and biological variables related to Oct4 expression

Factor	Number of cases	Oct4⁺ Cell percentage [N (%)]		p-value
Factor	Number of cases	Low	High	p-value
Age, months
< 18	312	272 (87.2)	40 (12.8)	0.008
≥ 18	240	189 (78.8)	51 (21.3)	0.008
Stage
L1 & L2	333	287 (86.2)	46 (13.8)	0.012
M & Ms	207	161 (77.8)	46 (22.2)	0.012
Category
NB & nodular GNB	503	414 (82.3)	89 (17.7)	0.007
GN & intermixed GNB	55	53 (96.4)	2 (3.6)	0.007
Differentiation degree
Undifferentiated	69	52 (75.4)	17 (24.6)	0.007
Poorly differentiated	345	286 (82.9)	59 (17.1)
Differentiating	99	92 (92.9)	7 (7.1)
Chromosomal Aberrations
Numerical	165	155 (93.3)	10 (6.1)	0.000
Segmental	287	215 (74.9)	72 (25.1)	0.000
MYCN status
Non-amplified	480	415 (86.5)	65 (13.5)	0.000
Amplified	80	54 (67.5)	26 (32.5)	0.000
11q
Not deleted	427	367 (85.9)	60 (14.1)	0.000
Deleted	106	76 (71.7)	30 (28.3)	0.000
Risk
Not High Risk	453	388 (85.7)	65 (14.3)	0.009
High Risk	110	83 (75.5)	27 (24.5)	0.009
Blood vessel size
Small area	230	198 (86.1)	32 (13.9)	0.037
Large area	230	181 (78.7)	49 (21.3)	0.037

Prognostic significance of differential Oct4⁺ cell percentage (low when Oct4⁺ cells ≤8.67% and high when Oct4⁺ cells > 8.67%) and the INRG pre-treatment classification factors in NBTs. (Chi-squared test). The risk parameter represents the combination of the INRG factors indicating whether or not NBTs patients are high-risk patients. The blood vessel size is a morphometric variable previously described as a parameter with prognostic implications in high-risk NB [33]. Statistical significance is shown as the obtained p-values (p-value< 0.050). N Number of cases, (%) Fraction of total cases

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