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Table 1 Statistically significant clinical and biological variables related to Oct4 expression

From: High Oct4 expression: implications in the pathogenesis of neuroblastic tumours

Factor Number of cases Oct4+ Cell percentage [N (%)] p-value
Low High
Age, months
 < 18 312 272 (87.2) 40 (12.8) 0.008
 ≥ 18 240 189 (78.8) 51 (21.3)
Stage
 L1 & L2 333 287 (86.2) 46 (13.8) 0.012
 M & Ms 207 161 (77.8) 46 (22.2)
Category
 NB & nodular GNB 503 414 (82.3) 89 (17.7) 0.007
 GN & intermixed GNB 55 53 (96.4) 2 (3.6)
Differentiation degree
 Undifferentiated 69 52 (75.4) 17 (24.6) 0.007
 Poorly differentiated 345 286 (82.9) 59 (17.1)
 Differentiating 99 92 (92.9) 7 (7.1)
Chromosomal Aberrations
 Numerical 165 155 (93.3) 10 (6.1) 0.000
 Segmental 287 215 (74.9) 72 (25.1)
MYCN status
 Non-amplified 480 415 (86.5) 65 (13.5) 0.000
 Amplified 80 54 (67.5) 26 (32.5)
11q
 Not deleted 427 367 (85.9) 60 (14.1) 0.000
 Deleted 106 76 (71.7) 30 (28.3)
Risk
 Not High Risk 453 388 (85.7) 65 (14.3) 0.009
 High Risk 110 83 (75.5) 27 (24.5)
Blood vessel size
 Small area 230 198 (86.1) 32 (13.9) 0.037
 Large area 230 181 (78.7) 49 (21.3)
  1. Prognostic significance of differential Oct4+ cell percentage (low when Oct4+ cells ≤8.67% and high when Oct4+ cells > 8.67%) and the INRG pre-treatment classification factors in NBTs. (Chi-squared test). The risk parameter represents the combination of the INRG factors indicating whether or not NBTs patients are high-risk patients. The blood vessel size is a morphometric variable previously described as a parameter with prognostic implications in high-risk NB [33]. Statistical significance is shown as the obtained p-values (p-value< 0.050). N Number of cases, (%) Fraction of total cases