Fig. 4

Cisplatin might activate the MLH1/c-Abl apoptosis signaling pathway in ADV-MLH1-infected cells. a Immunoblot analysis of p-c-Abl, cleaved caspase-9, cleaved caspase-3, cleaved PARP and Bcl-2 in ADV-MLH1-infected cells (+) 24, 48, and 72 h after exposure to 25 μmol cisplatin compared with same treated MLH1-deficient cells (−). b Immunoblot analysis of p-c-Abl, cleaved caspase-9, cleaved caspase-3, cleaved PARP and Bcl-2 in si-MLH1-transfected cells (T) 24, 48 and 72 h after exposure to 5 μmol cisplatin compared with same treated MLH1-proficient RL95–2 cells (−). U: not treated with cisplatin. *, P < 0.05; **P < 0.01