Table 4 Univariable and Multivariable Cox Proportional Hazards for prediction of progression in the well-balanced cohort
Predictors | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | |
Gender | ||||
Female | 1.00 (ref.) | – | Not included | |
Male | 1.40 (0.94, 2.07) | 0.095 | ||
Age,yr | ||||
≤ 45 | 1.00 (ref.) | – | 1.00 (ref.) | – |
> 45 | 1.42 (1.03, 1.96) | 0.032 | 1.49 (1.07, 2.06) | 0.017 |
ECOG scale | ||||
0–1 | 1.00 (ref.) | – | Not included | |
2 | 0.92 (0.13, 6.58) | 0.935 | ||
Smoking | ||||
No | 1.00 (ref.) | – | Not included | |
Yes | 1.18 (0.86, 1.64) | 0.309 | ||
NPC family history | ||||
No | 1.00 (ref.) | – | Not included | |
Yes | 0.96 (0.58, 1.59) | 0.882 | ||
Tumor stage | ||||
1 | 1.00 (ref.) | – | 1.00 (ref.) | – |
2 | 1.61 (0.46, 5.64) | 0.460 | 0.89 (0.24, 3.23) | 0.856 |
3 | 1.65 (0.52, 5.25) | 0.400 | 0.97 (0.29, 3.31) | 0.966 |
4 | 3.32 (1.05, 10.52) | 0.041 | 1.25 (0.36, 4.30) | 0.729 |
Node stage | ||||
0 | 1.00 (ref.) | – | Not included | |
1 | 1.12 (0.54, 2.29) | 0.764 | ||
2 | 1.11 (0.55, 2.24) | 0.767 | ||
3 | 1.54 (0.75, 3.18) | 0.240 | ||
UICC clinical stage | ||||
2 | 1.00 (ref.) | – | 1.00 (ref.) | – |
3 | 3.72 (0.51, 26.98) | 0.194 | 3.66 (0.50, 26.65) | 0.200 |
4 | 8.68 (1.21, 62.16) | 0.032 | 7.56 (1.05, 54.55) | 0.045 |
Radiotherapy | ||||
2DRT | 1.00 (ref.) | – | Not included | |
IMRT | 1.14 (0.16, 8.13) | 0.898 | ||
BMI, kg/m2 | ||||
< 18.5 | 1.00 (ref.) | – | 1.00 (ref.) | – |
18.5–23.9 | 0.63 (0.38, 1.03) | 0.066 | 0.64 (0.38, 1.06) | 0.080 |
24–27.9 | 0.68 (0.40, 1.15) | 0.150 | 0.79 (0.46, 1.35) | 0.384 |
≥ 28 | 0.31 (0.12, 0.77) | 0.012 | 0.35 (0.14, 0.88) | 0.025 |
EBVDNA, copy/mL | ||||
≤ 4000 | 1.00 (ref.) | – | 1.00 (ref.) | – |
> 4000 | 2.27 (1.63, 3.16) | < 0.001 | 2.07 (1.47, 2.91) | < 0.001 |
HGB, g/L | ||||
< 113 | 1.00 (ref.) | – | Not included | |
113–151 | 3.09 (0.76, 12.52) | 0.114 | ||
≥ 151 | 2.70 (0.66, 11.08) | 0.169 | ||
hs-CRP, g/mL | ||||
< 1.0 | 1.00 (ref.) | – | 1.00 (ref.) | – |
1.0–3.0 | 0.92 (0.60, 1.41) | 0.689 | 0.76 (0.49, 1.17) | 0.210 |
≥ 3.0 | 1.53 (1.03, 2.27) | 0.036 | 1.20 (0.80, 1.80) | 0.375 |
LDH, U/L | ||||
< 245 | 1.00 (ref.) | – | Not included | |
≥ 245 | 1.58 (0.97, 2.59) | 0.066 | ||
PICC-VTE | ||||
No | 1.00 (ref.) | – | 1.00 (ref.) | – |
Yes | 2.79 (1.97, 3.96) | < 0.001 | 2.92 (2.06, 4.15) | < 0.001 |