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Table 3 Univariate and multivariate analysis of prognostic factors of OS

From: Clinicopathological features, treatment patterns, and prognosis of squamous cell carcinoma of the breast: an NCDB analysis

Variables Univariate analysis Multivariate analysis
HR(95%CI) P HR(95%CI) P
Age
  < =50 1   1  
 50–60 1.13 (0.89–1.44) 0.301 1.10 (0.86–1.40) 0.445
  > 60 2.25 (1.86–2.74) < 0.001 2.11 (1.72–2.60) < 0.001
Race
 White 1   1  
 African American 1.51 (1.26–1.80) < 0.001 1.05 (0.87–1.27) 0.576
 Others 0.43 (0.24–0.77) 0.004 0.48 (0.27–0.85) 0.012
 Unknown 0.53 (0.24–1.19) 0.126 0.49 (0.22–1.10) 0.082
Comorbidity score
 Score 0 1   1  
 Score 1 2.17 (1.85–2.54) < 0.001 1.65 (1.40–1.95) < 0.001
Grade
 I 1   1  
 II 1.20 (0.94–1.54) 0.149 0.98 (0.76–1.26) 0.877
 III 2.05 (1.62–2.58) < 0.001 1.35 (1.05–1.74) 0.02
 Unknown/IV 1.86 (1.39–2.49) < 0.001 1.05 (0.77–1.42) 0.767
T-stage
 T0-T1 1   1  
 T2 2.24 (1.86–2.69) < 0.001 1.65 (1.35–2.03) < 0.001
 T3–4 5.63 (4.60–6.90) < 0.001 2.75 (2.14–3.55) < 0.001
 Tx 1.25 (1.04–1.51) 0.017 0.62 (0.45–0.85) 0.003
N-stage
 N0 1   1  
 N1 1.82 (1.49–2.22) < 0.001 1.77 (1.43–2.18) < 0.001
 N2–3 3.61 (2.90–4.49) < 0.001 2.18 (1.69–2.83) < 0.001
 Nx 1.12 (0.94–1.32) 0.197 0.95 (0.70–1.30) 0.764
M-stage
 M0 1   1  
 M1 8.47 (6.42–11.17) < 0.001 4.50 (3.29–6.16) < 0.001
 Mx 2.04 (1.74–2.39) < 0.001 1.90 (1.53–2.36) < 0.001
Histology
 Infiltrating Ductal Carcinoma 1   1  
 Squamous Cell Carcinoma 2.39 (2.06–2.77) < 0.001 1.37 (1.15–1.64) < 0.001
Lymphovascular invasiona
 Absence 1   Not included
 Presence 1.91 (1.37–2.67) < 0.001
 Not applicable/Unknown 2.18 (1.63–2.91) < 0.001
Estrogen Receptor
 Negative 1   1  
 Positive 0.53 (0.46–0.61) < 0.001 0.86 (0.67–1.10) 0.218
 Unknown 0.85 (0.67–1.08) 0.195 2.46 (0.60–10.15) 0.212
Progesterone Receptor
 Negative 1   1  
 Positive 0.56 (0.48–0.65) < 0.001 0.96 (0.76–1.20) 0.724
 Unknown 0.92 (0.73–1.16) 0.484 0.31 (0.08–1.27) 0.103
HER2a
 Negative 1   Not included
 Positive 0.83 (0.57–1.22) 0.347
 Borderline/Unknown 1.20 (0.87–1.66) 0.266
Surgery
 Breast-conserving surgery 1   1  
 Mastectomy 2.22 (1.90–2.59) < 0.001 1.26 (1.04–1.54) 0.02
 Others/Unknown 7.05 (5.77–8.62) < 0.001 6.57 (5.04–8.55) < 0.001
Radiation therapy
 No 1   1  
 Yes 0.54 (0.47–0.62) < 0.001 0.92 (0.77–1.10) 0.351
 Unknown 0.50 (0.24–1.05) 0.067 0.54 (0.25–1.17) 0.12
Chemotherapy
 No 1   1  
 Yes 0.89 (0.77–1.03) 0.116 0.67 (0.55–0.80) < 0.001
 Unknown 0.72 (0.53–0.99) 0.043 0.61 (0.43–0.85) 0.004
Endocrine therapy
 No 1   1  
 Yes 0.44 (0.38–0.51) < 0.001 0.60 (0.50–0.73) < 0.001
 Unknown 0.56 (0.40–0.78) < 0.001 0.77 (0.54–1.09) 0.145
  1. HR Hazard ratio, CI confidence interval
  2. aOnly patients diagnosed after 2010 were included
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