Table 4 Multivariable analysis by Cox regression model
Variable | Number | HR (95% CI) | P-value |
|---|---|---|---|
ECOG | |||
 0–1 | 164 | 1.00 |  |
 2 | 9 | 0.79 (0.34–1.85) | 0.586 |
Invasion to liver | |||
 No | 126 | 1.00 |  |
 Yes | 47 | 0.91 (0.59–1.39) | 0.648 |
Metastasis to liver | |||
 No | 99 | 1.00 |  |
 Yes | 74 | 1.63 (1.11–2.40) | 0.013 |
Metastasis to bone and muscle | |||
 No | 159 | 1.00 |  |
 Yes | 14 | 1.78 (0.93–3.42) | 0.081 |
NLR | |||
  < 3 | 75 | 1.00 |  |
  ≥ 3 | 98 | 1.65 (1.09–2.49) | 0.017 |
PLR | |||
  < 190 | 102 | 1.00 |  |
  ≥ 190 | 71 | 1.19 (0.79–1.77) | 0.405 |
Total bilirubin | |||
  ≤ 1.5 X ULN | 130 | 1.00 |  |
  > 1.5 X ULN | 43 | 1.56 (0.95–2.55) | 0.077 |
Transaminase | |||
  ≤ 1.5 X ULN | 120 | 1.00 |  |
  > 1.5 X ULN | 53 | 0.92 (0.59–1.45) | 0.723 |
CEA, ng/mL | |||
  < 5 | 103 | 1.00 |  |
  ≥ 5 | 70 | 1.50 (1.02–2.19) | 0.038 |
CA 19–9, U/mL | |||
  < 500 | 114 | 1.00 |  |
  ≥ 500 | 59 | 1.59 (1.01–2.50) | 0.043 |