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Table 4 Multivariable analysis by Cox regression model

From: Therapeutic outcomes and prognostic factors in unresectable gallbladder cancer treated with gemcitabine plus cisplatin

Variable Number HR (95% CI) P-value
ECOG
 0–1 164 1.00  
 2 9 0.79 (0.34–1.85) 0.586
Invasion to liver
 No 126 1.00  
 Yes 47 0.91 (0.59–1.39) 0.648
Metastasis to liver
 No 99 1.00  
 Yes 74 1.63 (1.11–2.40) 0.013
Metastasis to bone and muscle
 No 159 1.00  
 Yes 14 1.78 (0.93–3.42) 0.081
NLR
  < 3 75 1.00  
  ≥ 3 98 1.65 (1.09–2.49) 0.017
PLR
  < 190 102 1.00  
  ≥ 190 71 1.19 (0.79–1.77) 0.405
Total bilirubin
  ≤ 1.5 X ULN 130 1.00  
  > 1.5 X ULN 43 1.56 (0.95–2.55) 0.077
Transaminase
  ≤ 1.5 X ULN 120 1.00  
  > 1.5 X ULN 53 0.92 (0.59–1.45) 0.723
CEA, ng/mL
  < 5 103 1.00  
  ≥ 5 70 1.50 (1.02–2.19) 0.038
CA 19–9, U/mL
  < 500 114 1.00  
  ≥ 500 59 1.59 (1.01–2.50) 0.043
  1. ECOG Eastern Cooperative Oncology Group, CEA carcinoembryonic antigen, CA 19–9 carbohydrate antigen 19–9, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, CEA carcinoembryonic antigen, CA 19–9 carbohydrate antigen 19–9, ULN upper limit of normal
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