Skip to main content
Fig. 7 | BMC Cancer

Fig. 7

From: Semaphorin-5A maintains epithelial phenotype of malignant pancreatic cancer cells

Fig. 7

The putative mechanism is demonstrating how the loss of SEMA5A can trigger EMT. Representative schematic demonstrates the proposed mechanism of how the loss of SEMA5A leads to the activation of the PI3K/AKT pathway, which furthermore leads to inhibition of GSK-3β. This in turn results in the stabilization of β-catenin and Snail protein. Stabilization of β-catenin leads to active translocation of β-catenin from the cytoplasm into the nucleus, further leading to activation of WNT signaling. On the other hand, stabilization of Snail protein leads to the repression of transcription of E-cad. This suppression of E-cad transcription leads to a decrease in the E-cad protein levels, as well as leading to the induction of EMT

Back to article page
\