Adverse eventsa | Asymptomatic N = 135 | Symptomatic N = 548 | ||
---|---|---|---|---|
Grade 1–2 | Grade 3–4 | Grade 1–2 | Grade 3–4 | |
Any | 41 (30) | 39 (29) | 185 (34) | 218 (40) |
Anemiab | 12 (9) | 6 (4) | 64 (12) | 72 (13) |
Neutropeniac | 1 (< 1) | 5 (4) | 7 (1) | 9 (2) |
Thrombocytopeniad | 5 (4) | 2 (1) | 25 (5) | 22 (4) |
Constipation | 2 (1) | 0 | 23 (4) | 6 (1) |
Diarrhea | 15 (11) | 0 | 59 (11) | 4 (< 1) |
Nausea | 15 (11) | 0 | 74 (14) | 1 (< 1) |
Vomiting | 6 (4) | 0 | 27 (5) | 7 (1) |
Asthenia | 1 (< 1) | 0 | 22 (4) | 2 (< 1) |
Fatigue | 14 (10) | 1 (< 1) | 39 (7) | 12 (2) |
General physical health deterioration | 0 | 2 (1) | 7 (1) | 12 (2) |
Weight decreased | 9 (7) | 1 (< 1) | 34 (6) | 5 (< 1) |
Decreased appetite | 10 (7) | 0 | 34 (6) | 2 (< 1) |
Arthralgia | 1 (< 1) | 1 (< 1) | 20 (4) | 1 (< 1) |
Back pain | 5 (4) | 1 (< 1) | 24 (4) | 19 (3) |
Bone pain | 8 (6) | 3 (2) | 75 (14) | 26 (5) |
Spinal cord compression | 0 | 0 | 3 (< 1) | 19 (3) |