Fig. 5
From: Anti-cancer effect of dung beetle glycosaminoglycans on melanoma
Proposed role of dung beetle/bumblebee queen glycosaminoglycan against melanoma. CaG can strengthen ECM by increasing activity of TIMP-2 and adhesion activity on to collagen 1 to inhibit changes of ECM, leading to tumor cell invasion and progression along with increased activities of heparanase and angiotensin converting enzyme as well as fibronectin regulation (small amount ECM adhesion) in melanoma cells