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Fig. 3 | BMC Cancer

Fig. 3

From: Ras-ERK1/2 signaling contributes to the development of colorectal cancer via regulating H3K9ac

Fig. 3

Ras-ERK1/2 repressed H3K9 acetylation to affect the transcription of Ras downstream genes. SW48 cells were transfected with pEGFP-H3, pEGFP-K-RasG12V/T35S plus pEGFP-H3, or pEGFP-K-RasG12V/T35S plus pEGFP-H3K9Q. a RT-qPCR was performed to assess the expression levels of these genes. b ChIP was conducted to assess the levels of H3K9ac when different genes were expressed. * P < 0.05; ** P < 0.01; *** P < 0.001

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