Skip to main content
Fig. 7 | BMC Cancer

Fig. 7

From: The interactions of novel mononuclear platinum-based complexes with DNA

Fig. 7

Images of 1% (v/v) native agarose gels and their respective semi-log scatter plots, showing changes in the apparent molecular weight of the native pUC19 DNA conformations following treatment with (a) cisplatin, (b) [Pt(RR-DACH)Cl2], (c) [Pt(RR-DACP)Cl2], (d) [Pt(SS-DACP)Cl2] and (e) [Pt(4FH)Cl2]. Bands corresponding to the OC, SCI and SCII conformations of pUC19, are indicated on the left-hand side of each gel image. The DMF solvent control sample (pUC19 without drug treatment) is situated to the left of the 1 kb ladder. All other lanes contain DNA samples treated with increasing concentration of compound as indicated in μM above each gel image. The changes in apparent molecular weight of each pUC19 conformation is plotted on the semi-log scatter graphs to the right of each image. The band migration for the OC, SCI and SCII plasmid conformations are represented by red, green and blue lines, respectively. The error bars shown represent the SEM determined across three separate experiments

Back to article page
\