Fig. 1
From: The interactions of novel mononuclear platinum-based complexes with DNA
The chemical structures of cisplatin, RR-DACH and the three novel platinum-based compounds used in this study. All compounds used in this study consist of a single platinum atom and two chloride atoms arranged in the cis configuration. Note that (a) cisplatin is a square planar compound containing two ammine groups attached to the central platinum atom. RR-DACH, contains an RR-configured cyclohexane ligand attached to two ammine groups. The novel compounds (c) [Pt(SS-DACP)Cl2] and (d) [Pt(RR-DACP)Cl2] consist of isomeric configured cyclopentane ligands. The novel compound (e) [Pt(4FH)Cl2] contains symmetrical fluorobenzoic hydrazide groups attached to ammine groups on either side of the platinum atom