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Table 2 Adverse events

From: A phase II trial of recombinant MAGE-A3 protein with immunostimulant AS15 in combination with high-dose Interleukin-2 (HDIL2) induction therapy in metastatic melanoma

Event

Grade 3/4 (n)

%

Total (n)

%

Any event

13

76%

17

100%

Anemia

4

24%

14

82%

Anorexia

0

0%

6

35%

Arthralgia

1

6%

7

41%

Chills

0

0%

10

59%

Constipation

0

0%

4

24%

Cough

0

0%

3

18%

Decreased urine output

1

6%

1

6%

Diarrhea

1

6%

7

41%

Dry skin

0

0%

15

88%

Dyspnea

0

0%

3

18%

Edema

0

0%

14

82%

Fatigue

0

0%

14

82%

Fever

0

0%

5

29%

Headache

0

0%

7

41%

Hyperglycemia

1

6%

6

35%

Hyperkalemia

1

6%

4

24%

Hypermagnesiumia

1

6%

1

6%

Hypertension

1

6%

2

12%

Hyperuricemia

2

12%

4

24%

Hypoalbuminemia

8

47%

14

82%

Hypoglycemia

0

0%

5

29%

Hyponatremia

1

6%

2

12%

Hypophosphatemia

0

0%

3

18%

Hypotension

0

0%

7

41%

Increased alanine aminotransferase

0

0%

3

18%

Increased alkaline phosphatase

0

0%

3

18%

Increased aspartate aminotransferase

0

0%

5

29%

Increased bilirubin

2

12%

6

35%

Increased Creatinine

2

12%

6

35%

Injection site reaction

0

0%

5

29%

Lymphopenia

3

18%

4

24%

Myalgia

0

0%

10

59%

Nausea

0

0%

11

65%

Pain

1

6%

12

71%

Peripheral sensory neuropathy

0

0%

7

41%

Pruritus

1

6%

12

71%

Rash

1

6%

8

47%

Thrombocytopenia

1

6%

2

12%

Tinnitus

0

0%

3

18%

Ventricular tachycardia

1

6%

2

12%

Vomiting

0

0%

7

41%

Weight loss

0

0%

3

18%

  1. Events occurring in > 15% of patients and all Grade 3/4 adverse events