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Table 3 Grade-3–4 acute toxicities between the two groups of patients

From: Liposomal paclitaxel versus docetaxel in induction chemotherapy using Taxanes, cisplatin and 5-fluorouracil for locally advanced nasopharyngeal carcinoma

Adverse event (toxicity grade)

Liposomal PTX (n = 103)

Docetaxel (n = 287)

P

0–2 (%)

3–4 (%)

0–2 (%)

3–4 (%)

Leukopenia

99(96.1)

4(3.9)

201(70.0)

86(30.0)

< 0.001c

Neutropenia

81(78.6)

22(21.4)

152(53.0)

135(47.0)

< 0.001a

Anemia

103(100)

0(0.0)

282(98.3)

5(1.7)

0.331b

Thrombocytopenia

103(100)

0(0.0)

283(98.6)

4(1.4)

0.577b

ALT increase

102(99.0)

1(1.0)

283(98.6)

4(1.4)

1.000c

AST increase

103(100)

0(0.0)

283(98.6)

0(0.0)

–

Creatinine increase

103(100)

0(0.0)

283(98.6)

0(0.0)

–

BUN increase

103(100)

0(0.0)

283(98.6)

0(0.0)

–

Nausea

101(98.1)

2(1.9)

279(97.2)

8(2.8)

1.000 b

Vomiting

97(94.2)

6(5.8)

263(91.6)

24(8.4)

0.520 a

Mucositis

103(100)

0(0.0)

286(99.7)

1(0.3)

1.000 b

Neuropathy

103(100)

0(0.0)

287(100)

0(0.0)

–

  1. PTX paclitaxel, ALT alanine aminotransferase, AST aspartate aminotransferase, BUN blood urea nitrogen
  2. aP value was calculated using the chi-square test. bP value was calculated using Fisher’s exact test. cP value was calculated by correction for continuity chi-square test