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Table 4 Correlation between prognosis in patients harbouring SF3B1 and EIF1AX changes versus wildtype patients. Deceased patients indicated by †; survival correct to January 2018. The two patients highlighted in grey might represent secondary orbital melanoma with an occult uveal origin

From: Detection of mutations in SF3B1, EIF1AX and GNAQ in primary orbital melanoma by candidate gene analysis

Case no.

Prognosis group

Orbital progression

Systemic progression

Survival (months)

SF3B1 p.R625H

EIF1AX p.N4S

1

Poor

No

Yes

3†

  

2

 

No

Yes

4†

  

13

Intermediate

Yes

Yes

25

  

5

 

Yes

No

37

  

6

 

No

Yes

18†

  

8

 

Yes

Yes

91

  

9

Good

Yes (after 13 years)

Yes (after 13 years)

174†

YES

 

10

 

No

No

26

 

YES

11

 

No

No

188

YES

 

12

 

No

No

22

YES

 

4

 

Unknown

Unknown

35

YES

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