Table 1 Summary of clinical characteristics of 11 patients with primary orbital melanoma. “RT” denotes fractionated external beam radiotherapy. † indicates a deceased patient
Case no. | Gender | Age at onset (years) | Side | Primary treatment of orbital disease | Orbital progression | Time orbital treatment to orbital recurrence (months) | Systemic progression | Time orbit to systemic disease (months) | Systemic therapy | Survival (months) | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|
1 | F | 81 | R | Debulking | N | – | Y | 0 | 3† | Too unwell for adjuvant radiotherapy | |
2 | M | 40 | L | Exenteration | N | – | Y | 0 | 4† | Too unwell for adjuvant radiotherapy | |
4 | F | 58 | L | Exenteration | Unknown | – | Unknown | – | 25 | Patient declined adjuvant radiotherapy & active follow up | |
5 | M | 45 | L | Debulking + RT | Y | 6 | N | – | 37 | Exenteration after orbital progression | |
6 | F | 84 | R | Exenteration + RT | N | – | Y | 12 | Palliative RT for bone metastases | 18† | Conjunctival melanosis |
8 | M | 45 | L | Debulking + RT | Y | 7 | Y | 45 | Liver resection | 91 | Nevus of Ota Exenteration after orbital progression |
9 | F | 47 | L | Debulking + RT | Y | 161 | Y | 168 | Nil active | 174† | Conjunctival nevus Late exenteration |
10 | M | 46 | R | Debulking +RT | N | – | N | – | 26 | ||
11 | F | 43 | L | Debulking + RT | N | – | N | – | 188 | West African | |
12 | F | 70 | L | Debulking +RT | N | – | N | – | 22 | ||
13 | M | 55 | R | Debulking + RT | Y | 2 | Y | 5 | Immunotherapy | 35 | Immunotherapy for progressive systemic and orbital disease |