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Table 3 Univariate and multivariate analyses were performed using Cox’s proportional hazard model in patients with N3 gastric cancer

From: A modified subclassification to evaluate the survival of patients with N3 gastric cancer: an international database study

Characteristic Univariate analysis Multivariate analysis 1 Multivariate analysis 2
5-year OS (%) χ2 P HR (95% CI) P HR (95% CI) P
Age at diagnosis, y   79.168 < 0.001     
  < 65 27.9    1   1  
  ≥ 65 16.3 1.47 (1.35–1.60) < 0.001 1.47 (1.35–1.60) < 0.001
Gender   0.617 0.432     
 Male 22.2       
 Female 22.6     
Ethnicity   80.923 < 0.001     
 White 14.4    1   1  
 Asian 27.4 0.66 (0.59–0.73) < 0.001 0.66 (0.60–0.73) < 0.001
 Black 15.8 1.02 (0.88–1.19) 0.781 1.03 (.88–1.20) 0.748
 Hispanic 21.4 0.85 (0.74–0.98) 0.028 0.84 (0.72–0.97) 0.014
 Native American 15.8 0.86 (0.52–1.42) 0.563 0.83 (0.50–1.36) 0.454
Histology   0.223 0.637     
 G1/G2 22.7       
 G3/G4 22.3     
Tumor size, mm   17.131 < 0.001     
  ≤ 60 24.6    1   1  
  > 60 20.0 1.02 (0.94–1.12) 0.581 1.01 (0.93–1.10) 0.864
T-category   46.870 < 0.001     
 T1 45.5    1   1  
 T2 39.1 1.18 (0.79–1.75) 0.431 1.12 (0.75–1.67) 0.579
 T3 24.4 1.66 (1.18–2.34) 0.004 1.60 (1.14–2.26) 0.007
 T4a 20.3 1.86 (1.32–2.61) < 0.001 1.77 (1.26–2.48) 0.001
 T4b 18.0 2.18 (1.54–3.10) < 0.001 2.06 (1.45–2.93) < 0.001
Type of surgery   1.255 0.263     
 Proximal/distal gastrectomy 22.8       
 Total gastrectomy 21.7     
N-category   143.8 < 0.001     
 N3a 28.3    1   1  
 N3b 13.5 1.56 (1.43–1.70) < 0.001 1.13 (0.99–1.29) 0.083
Modified N-category   157.67 < 0.001     
 Modified N3a 30.7      1  
 Modified N3b 14.5    1.51 (1.32–1.73) < 0.001