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Fig. 3 | BMC Cancer

Fig. 3

From: Estrogen receptor signaling regulates the expression of the breast tumor kinase in breast cancer cells

Fig. 3

BRK staining in invasive and lymph node metastatic carcinomas show higher expression in ER-positive tumors. Representative immunohistochemical staining of BRK (a-f) in human breast TMA. tumor samples selected form a 50 cases/100 cores array (BR10010a, USBIOMAX, USA). The TMA was a 50 cases/100 cores array containing 50 invasive carcinoma samples and matched 50 lymph node metastasis samples. The age and clinical details of each case including TNM and pathology grade, ER, PR and HER2 status were available (http://www.biomax.us/tissue-arrays/Breast/BR10010a). TNBC cases were those that were negative for ER, PR and HER2. The absolute values for the total intensity and total number of positive BRK staining were provided by the pathologists at USBIOMAX. LNM = lymph node metastasis, IDC = invasive ductal carcinoma. The Intensity ratio was calculated as Total intensity values of LNM over IDC. A2/No 2, F2/No 52, c2/No 22, H2/No 72, A10/No 10, and F10/No 60 designations, located at the lower hand corner of each sample, represent the position of the sample on the BR10010a (http://www.biomax.us/tissue-arrays/Breast/BR10010a)

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