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Fig. 3 | BMC Cancer

Fig. 3

From: Dihomo-γ-linolenic acid inhibits xenograft tumor growth in mice bearing shRNA-transfected HCA-7 cells targeting delta-5-desaturase

Fig. 3

Delta-5-desaturase knockdown leads to accumulation of dihomo-γ-linolenic acid and 8-hydroxyoctanoic acid in xenograft tumor tissues. a LC/MS profile of dihomo-γ-linolenic acid levels in all groups of tumor tissues; b Calculated dihomo-γ-linolenic acid/arachidonic acid ratio from LC/MS analysis in different tumor tissues. The dashed line represents the basal level of dihomo-γ-linolenic acid/arachidonic acid ratio in tumors from mice receiving no dihomo-γ-linolenic acid supplementation; c GC/MS profile of 8-hydroxyoctanoic acid production from delta-5-desaturase-WT and delta-5-desaturase-KD tumor tissues. The dashed line represents the threshold level of 8-hydroxyoctanoic acid that can be only reached in delta-5-desaturase-KD tumors; d LC/MS profile of PGE2 from delta-5-desaturase-WT and delta-5-desaturase-KD tumor tissue. All of the data represent mean ± standard deviation with n = 6. *: significant difference with p < 0.05

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BMC Cancer

ISSN: 1471-2407

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