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Fig. 8 | BMC Cancer

Fig. 8

From: A novel detection methodology for HER2 protein quantitation in formalin-fixed, paraffin embedded clinical samples using fluorescent nanoparticles: an analytical and clinical validation study

Fig. 8

Scatter plot comparison of PID score to ISH data from the method comparison study. Graphs A.i. (R2 = 0.5732) and A.ii. (R2 = 0.5692) compare PID/cell and PID ROI100μm2 to ISH ratio, respectively. Graphs B.i. (R2 = 0.719) and B.ii. (R2 = 0.6847) compare PID/cell and PID ROI100μm2 to ISH HER2 copy number, respectively. The red box represents discordant results between PID analysis and ISH analysis utilizing the PID experimental thresholds from the neoadjuvant study and a ISH ratio of 2 or a HER2 copy number of 6 that resulted in a negative PID score but a positive ISH score. The blue box represents discordant cases that had a positive PID but a negative ISH result

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