Characteristics | OS | DFS | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||||
Median | P | HR | P | 95%CI | Median | P | HR | P | 95%CI | |
Age | Â | 0.131 | Â | Â | Â | Â | 0.573 | Â | Â | Â |
60–70 | 15.8 |  |  |  |  | 14 |  |  |  |  |
≥70 | 8.2 |  |  |  |  | 10 |  |  |  |  |
Sex | Â | 0.858 | Â | Â | Â | Â | 0.906 | Â | Â | Â |
Male | 12.9 | Â | Â | Â | Â | 13.8 | Â | Â | Â | Â |
Female | 14.6 | Â | Â | Â | Â | 13 | Â | Â | Â | Â |
ECOG |  | 0.005 | 1.748 | 0.075 | 0.945–3.233 |  | 0.109 |  |  |  |
0–2 | 15.7 |  |  |  |  | 13.8 |  |  |  |  |
≥3 | 6 |  |  |  |  | 5 |  |  |  |  |
FAB classification | Â | 0.67 | Â | Â | Â | Â | 0.451 | Â | Â | Â |
M0 | 4.5 | Â | Â | Â | Â | / | Â | Â | Â | Â |
M1 | 10.2 | Â | Â | Â | Â | 10 | Â | Â | Â | Â |
M2 | 13.9 | Â | Â | Â | Â | 13 | Â | Â | Â | Â |
M4 | 8.7 | Â | Â | Â | Â | 14.1 | Â | Â | Â | Â |
M5 | 11.3 | Â | Â | Â | Â | 14.2 | Â | Â | Â | Â |
M6 | 15.7 | Â | Â | Â | Â | 6.3 | Â | Â | Â | Â |
Primary karyotype |  | 0.006 | 2.272 | 0.010 | 1.213–4.258 |  | 0.045 | 1.768 | 0.127 | 0.850–3.680 |
Intermediate | 15.9 | Â | Â | Â | Â | 15.2 | Â | Â | Â | Â |
Poor | 8.2 | Â | Â | Â | Â | 7 | Â | Â | Â | Â |
FLT3-ITD mutation |  | 0.005 | 2.669 | 0.007 | 1.304–5.461 |  | 0.352 |  |  |  |
Positive | 4 | Â | Â | Â | Â | 7.6 | Â | Â | Â | Â |
Negative | 14.8 | Â | Â | Â | Â | 13.8 | Â | Â | Â | Â |
NPM1 mutation | Â | 0.987 | Â | Â | Â | Â | 0.782 | Â | Â | Â |
Positive | 16.5 | Â | Â | Â | Â | 14.2 | Â | Â | Â | Â |
Negative | 13.9 | Â | Â | Â | Â | 10 | Â | Â | Â | Â |
CEBPα mutation |  | 0.132 |  |  |  |  | 0.089 |  |  |  |
Positive | 23.4 | Â | Â | Â | Â | 17.4 | Â | Â | Â | Â |
Negative | 13.9 | Â | Â | Â | Â | 10 | Â | Â | Â | Â |
C-Kit mutation | Â | 0.067 | Â | Â | Â | Â | 0.987 | Â | Â | Â |
Positive | 5 | Â | Â | Â | Â | 16 | Â | Â | Â | Â |
Negative | 14.6 | Â | Â | Â | Â | 11.9 | Â | Â | Â | Â |
Day-14 platelet count |  | 0.003 | 0.571 | 0.091 | 0.298–1.094 |  | 0.006 | 0.468 | 0.035 | 0.231–0.947 |
PLT ≥ 100 × 109/L | 31 |  |  |  |  | 16.9 |  |  |  |  |
PLT < 100 × 109/L | 10.1 |  |  |  |  | 8.9 |  |  |  |  |