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Table 5 Prognostic factors of overall survival and disease-free survival

From: Early recovery of the platelet count after decitabine-based induction chemotherapy is a prognostic marker of superior response in elderly patients with newly diagnosed acute myeloid leukaemia

Characteristics

OS

DFS

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

Median

P

HR

P

95%CI

Median

P

HR

P

95%CI

Age

 

0.131

    

0.573

   

60–70

15.8

    

14

    

≥70

8.2

    

10

    

Sex

 

0.858

    

0.906

   

Male

12.9

    

13.8

    

Female

14.6

    

13

    

ECOG

 

0.005

1.748

0.075

0.945–3.233

 

0.109

   

0–2

15.7

    

13.8

    

≥3

6

    

5

    

FAB classification

 

0.67

    

0.451

   

M0

4.5

    

/

    

M1

10.2

    

10

    

M2

13.9

    

13

    

M4

8.7

    

14.1

    

M5

11.3

    

14.2

    

M6

15.7

    

6.3

    

Primary karyotype

 

0.006

2.272

0.010

1.213–4.258

 

0.045

1.768

0.127

0.850–3.680

Intermediate

15.9

    

15.2

    

Poor

8.2

    

7

    

FLT3-ITD mutation

 

0.005

2.669

0.007

1.304–5.461

 

0.352

   

Positive

4

    

7.6

    

Negative

14.8

    

13.8

    

NPM1 mutation

 

0.987

    

0.782

   

Positive

16.5

    

14.2

    

Negative

13.9

    

10

    

CEBPα mutation

 

0.132

    

0.089

   

Positive

23.4

    

17.4

    

Negative

13.9

    

10

    

C-Kit mutation

 

0.067

    

0.987

   

Positive

5

    

16

    

Negative

14.6

    

11.9

    

Day-14 platelet count

 

0.003

0.571

0.091

0.298–1.094

 

0.006

0.468

0.035

0.231–0.947

PLT ≥ 100 × 109/L

31

    

16.9

    

PLT < 100 × 109/L

10.1

    

8.9

    
  1. OS overall survival, DFS disease-free survival, HR hazard ratio, CI confidence interval, ECOG Eastern Cooperative Oncology Group, PLT platelet